International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 9, Issue:12, December, 2020

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(12): 3197-3210

Comparative Pharmacokinetics of the Orally Administered Sub-lethal Doses of Miconazole Nitrate in Labeo rohita
Mukta Singh, Himadri Saha and Ratan Kumar Saha*
Department of Aquatic Health and Environment, College of Fisheries,CAU, Lembucherra, Agartala, Tripura-799210, India
*Corresponding author

The present study examined the pharmacokinetics of imidazole antifungal drug Miconazole nitrate (MCZ) in one of the most economically important aquaculture carp Labeo rohita. The pharmacokinetics study of MCZ was conducted after the single time administration of three sub-lethal doses (T1-6.30 mg kgBW-1, T2- 12.61 mg kgBW-1 and T3-25.22 mg kgBW-1) in the feed. Plasma drug concentrations of MCZ were determined using high performance liquid chromatography (HPLC) with a limit of detection 0.032 µg ml-1. The calibration curves were observed to be linear in the investigated areas of 0.5-25 µg ml-1 of MCZ and the recovery rates were 88.70 to 99.03 %. The peak plasma concentrations (Cmax) in rohu varied significantly (p<0.05) in all the three doses at 6 to 8 h (Tmax) and the order of magnitude for maximum concentrations were T3 (20.28 µg ml-1) > T2 (9.44 µg ml-1) > T1 (5.35 µg ml-1). The calculated half-lives (t1/2β) and the area under the plasma concentration-time curve (AUC) was observed to be varied from 30 h to 77 h and 263.11 μg*h ml−1 to 1048.99 μg*h ml−1 respectively. The mean residence time and the half value duration of the drug in plasma also varied significantly (p<0.05) in all the three orally administered doses. These findings support the potential of MCZ being absorbed and eliminated rapidly with a marked drug concentration in the blood of rohu, hence, can be recommended as a suitable candidate for the treatment of fungal infections in carps based on the observed pharmacokinetics data.

Keywords: miconazole nitrate, Labeo rohita, Pharmacokinetics, Elimination

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Mukta Singh, Himadri Saha and Ratan Kumar Saha. 2020. Comparative Pharmacokinetics of the Orally Administered Sub-lethal Doses of Miconazole Nitrate in Labeo rohita.Int.J.Curr.Microbiol.App.Sci. 9(12): 3197-3210. doi:
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