National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692 Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown etiology. Midkine (MK) is a pleiotropic growth factor prominently expressed during embryogenesis but down-regulated to negligible levels in healthy adults. MK is involved in cell proliferation, differentiation, migration, and survival. The present study aimed to investigate the role of serum midkine level in rheumatoid arthritis (RA) patients and to analyze the relationship between the serum MK level and disease activity. Blood samples were collected from 60 patients with rheumatoid arthritis and twenty healthy individuals served as control group. Serum level of Midkine was measured by Enzyme Linked ImmunoSorbent Assay (ELISA). Other markers including Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and Anti-CCP were estimated. Serum Midkine level was significantly higher in active RA patients than in inactive RA patients and healthy controls. It correlated positively with DAS-28 score in RA patients. ROC curve analysis revealed that the diagnostic efficacy of midkine was of 0.843 and the prediction power of RA activity was of 0.825. MK was significantly increased in serum of RA patients, and its level was correlated with several clinical markers of RA and DAS-28 score. So, the serum MK level could be a marker of RA disease activity.
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