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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2022: 95.28
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28
For more details click here
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Original Research Articles                      Volume : 9, Issue:9, September, 2020
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
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Int.J.Curr.Microbiol.App.Sci.2020.9(9): 3252-3259
DOI: https://doi.org/10.20546/ijcmas.2020.909.403


In-vitro Analysis of Ganoderma lucidum Extract Induces Cell Cycle Arrest and Apoptosis in MCF-12 Human Breast Cancer Cell
Reetu Gour1 and A.P. Garg2
1Department of Microbiology, Ch. Charan Singh University, Meerut-250004 (India)
2School of Biological Engineering & Life Sciences, Shobhit Institute of Engineering & Technology, (Deemed- to-be-University), Modipuram, Meerut-250110, India
*Corresponding author
Abstract:

Ppharmalogical and clinical application of water extracts of Ganoderma lucidum have been extensively documented, in short is known regarding its alcohol extract. In this research work, the anti-tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF-12 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a time and dose dependent manner, which might be mediated through up-regulation of p21/Waf1 and down-regulation of cyclin D1. Further, this compound can directly induce apoptosis in MCF-12 cells, which might be mediated through up-regulation of a proapoptotic Bax protein and not by the immune system. Our research suggests that there are multiple mechanisms underlying the anti-tumor effects of Ganoderma lucidum.


Keywords: Ganoderma lucidum, Breast cancer, Cell cycle, Apoptosis

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How to cite this article:

Reetu Gour and Garg, A.P. 2020. In-vitro Analysis of Ganoderma lucidum Extract Induces Cell Cycle Arrest and Apoptosis in MCF-12 Human Breast Cancer Cell.Int.J.Curr.Microbiol.App.Sci. 9(9): 3252-3259. doi: https://doi.org/10.20546/ijcmas.2020.909.403
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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