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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 3252-3259
DOI: https://doi.org/10.20546/ijcmas.2020.909.403


In-vitro Analysis of Ganoderma lucidum Extract Induces Cell Cycle Arrest and Apoptosis in MCF-12 Human Breast Cancer Cell
Reetu Gour1 and A.P. Garg2
1Department of Microbiology, Ch. Charan Singh University, Meerut-250004 (India)
2School of Biological Engineering & Life Sciences, Shobhit Institute of Engineering & Technology, (Deemed- to-be-University), Modipuram, Meerut-250110, India
*Corresponding author
Abstract:

Ppharmalogical and clinical application of water extracts of Ganoderma lucidum have been extensively documented, in short is known regarding its alcohol extract. In this research work, the anti-tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF-12 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a time and dose dependent manner, which might be mediated through up-regulation of p21/Waf1 and down-regulation of cyclin D1. Further, this compound can directly induce apoptosis in MCF-12 cells, which might be mediated through up-regulation of a proapoptotic Bax protein and not by the immune system. Our research suggests that there are multiple mechanisms underlying the anti-tumor effects of Ganoderma lucidum.


Keywords: Ganoderma lucidum, Breast cancer, Cell cycle, Apoptosis
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How to cite this article:

Reetu Gour and Garg, A.P. 2020. In-vitro Analysis of Ganoderma lucidum Extract Induces Cell Cycle Arrest and Apoptosis in MCF-12 Human Breast Cancer Cell.Int.J.Curr.Microbiol.App.Sci. 9(9): 3252-3259. doi: https://doi.org/10.20546/ijcmas.2020.909.403