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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(9): 1481-1489
DOI: https://doi.org/10.20546/ijcmas.2020.909.187


In vitro and In vivo Antibacterial and Anti-inflammatory Properties of Linalool
D. Varia1*, J. H. Patel1, F. D. Modi1, P. D. Vihol2 and S. K. Bhavsar3
1Department of Pharmacology & Toxicology, 2Department of Pathology, College of Veterinary Science & Animal Husbandry, Navsari Agricultural University, Navsari – Gujarat (396450), India
3Department of Pharmacology & Toxicology, AAU, Anand, India
*Corresponding author
Abstract:

The present study was planned to determine in vitro and in vivo antibacterial and anti-inflammatory properties of Linalool. In vitro antibacterial activity of Linalool was determined by micro broth dilution technique and MICs were observed as1.25, 1.25, 1.25, 0.63, 1.25, 0.63 and 1.25 mg/ml against Staphylococcus aureus, Streptococcus pyogenus, Bacillus subtillis, Escherichia coli, Salmonella typhimurium, Pseudomonas aerugonosa and Proteus mirabilis, respectively. In vivo antibacterial efficacy of Linalool was determined in neutropenic rat thigh infection model and significant antibacterial efficacy was observed as compared to growth control with bacterial colony count 4.07 ± 0.05 Log10cfu/ml. In vitro anti-inflammatory activity was tested for their ability to inhibit COX-2 enzyme by measuring PGE2 level and determination of NO production in LPS treated RAW264.7 macrophage cells. At all concentrations of Linalool (10, 50 and 100 µM) found to have significant inhibition of NO and PGE2 production compared with LPS control group. In vivo anti-inflammatory activity of Linalool (100 mg/kg) was assessed using the carrageenan-induced rat paw edema model at different time intervals following intramuscular injection and observed significant percent inhibition of edema volume compared with carrageenan control group.


Keywords: Linalool, Antibacterial, Anti-inflammatory, Carrageenan, Lipopolysaccharide, Rat
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How to cite this article:

Varia, R. D., J. H. Patel, F. D. Modi, P. D. Vihol and Bhavsar, S. K. 2020. In vitro and In vivo Antibacterial and Anti-inflammatory Properties of Linalool.Int.J.Curr.Microbiol.App.Sci. 9(9): 1481-1489. doi: https://doi.org/10.20546/ijcmas.2020.909.187