National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The present study was planned to determine in vitro and in vivo antibacterial and anti-inflammatory properties of Linalool. In vitro antibacterial activity of Linalool was determined by micro broth dilution technique and MICs were observed as1.25, 1.25, 1.25, 0.63, 1.25, 0.63 and 1.25 mg/ml against Staphylococcus aureus, Streptococcus pyogenus, Bacillus subtillis, Escherichia coli, Salmonella typhimurium, Pseudomonas aerugonosa and Proteus mirabilis, respectively. In vivo antibacterial efficacy of Linalool was determined in neutropenic rat thigh infection model and significant antibacterial efficacy was observed as compared to growth control with bacterial colony count 4.07 ± 0.05 Log10cfu/ml. In vitro anti-inflammatory activity was tested for their ability to inhibit COX-2 enzyme by measuring PGE2 level and determination of NO production in LPS treated RAW264.7 macrophage cells. At all concentrations of Linalool (10, 50 and 100 µM) found to have significant inhibition of NO and PGE2 production compared with LPS control group. In vivo anti-inflammatory activity of Linalool (100 mg/kg) was assessed using the carrageenan-induced rat paw edema model at different time intervals following intramuscular injection and observed significant percent inhibition of edema volume compared with carrageenan control group.
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