National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Halquinol, a quinoline derivative having antibacterial, antifungal and antiprotozoal activity was introduced across the world to overcome common challenges of modern poultry and swine farming, like pathogenic microbial infections and growth promotion aspects. In Asian countries including India, halquinol is being extensively used as growth promoter in poultry and to control intestinal infections, which may contribute towards the development of resistance against it. And also, as minimum inhibitory concentration (MIC) of antimicrobials against microbial pathogens changes with place and time, the present study was conducted to determine the current MIC of halquinol against local pathogenic bacterial isolates from poultry. In the present study two individual isolates from poultry viz., Salmonella gallinarum and Escherichia coli were used as test bacteria. The MIC of halquinol was determined by employing broth dilution technique following standard protocol. The MIC was determined as the lowest concentration of halquinol that completely inhibited the growth of bacteria. The MIC of halquinol against both the local pathogenic isolates from poultry viz: Escherichia coli and Salmonella gallinarum was 4 µg/mL. Thus, despite the widespread usage, the development of resistance against halquinol did not cross the global optimal MIC reported in the year 2015
Halquinol, pathogenic bacterial isolates, poultry, MIC
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