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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(6): 874-884
DOI: https://doi.org/10.20546/ijcmas.2020.906.110


Effect of Metformin in Rat Model of Vincristine Induced Peripheral Neuropathy
Ola Mousa Salem*, Sabiha El-MandohHedeya, Fleur FathyAbd El-Menem, DareenAbd El-Aziz Mohamed Ali and Amira Ahmed El- Saadany
Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Chemotherapy has many side effects one of it is peripheral neuropathy. Aim of the study is to examine the effect of metformin either alone or in combination with pregabalin on chemotherapy induced peripheral neuropathy (CIPN). CIPN was induced in 40 spraguedawley rats; the study was hold on 5 equal groups; group I (normal control group), group II (diseased group), group III, (metformin treated group), group IV (pregabalin treated group), group V (metformin + pregabalin treated group). Tail immersion, acetone drop tests, serum malondaldehyde (MDA), serum tumor necrosis factor (TNFα), serum nerve growth factor (NGF) and tissue reduced glutathione (GSH), were assessed. Sciatic nerves were excised for histological examination and immunohistochemistery detection of caspase 3. Results: Combined administration of metformin and pregabalin significantly ameliorates neuropathy detected by attenuation of thermal hyperalgesia and allodynia along with restoration of oxidative stress markers (MDA & GSH), decrease of inflammatory mediators (TNFα), caspase 3 and increase of (NGF). Current results proved that Metformin has neuroprotective effect in addition to pregabalin that ameliorates vincristine induced peripheral neuropathy.


Keywords: Chemotherapy Induced Peripheral Neuropathy (CIPN), Pregabalin, Metformin and nerve growth factor (NGF)
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How to cite this article:

Ola Mousa Salem, Sabiha El-MandohHedeya, Fleur FathyAbd El-Menem, DareenAbd El-Aziz Mohamed Ali and Amira Ahmed El- Saadany. 2020. Effect of Metformin in Rat Model of Vincristine Induced Peripheral Neuropathy.Int.J.Curr.Microbiol.App.Sci. 9(6): 874-884. doi: https://doi.org/10.20546/ijcmas.2020.906.110