National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Chemotherapy has many side effects one of it is peripheral neuropathy. Aim of the study is to examine the effect of metformin either alone or in combination with pregabalin on chemotherapy induced peripheral neuropathy (CIPN). CIPN was induced in 40 spraguedawley rats; the study was hold on 5 equal groups; group I (normal control group), group II (diseased group), group III, (metformin treated group), group IV (pregabalin treated group), group V (metformin + pregabalin treated group). Tail immersion, acetone drop tests, serum malondaldehyde (MDA), serum tumor necrosis factor (TNFα), serum nerve growth factor (NGF) and tissue reduced glutathione (GSH), were assessed. Sciatic nerves were excised for histological examination and immunohistochemistery detection of caspase 3. Results: Combined administration of metformin and pregabalin significantly ameliorates neuropathy detected by attenuation of thermal hyperalgesia and allodynia along with restoration of oxidative stress markers (MDA & GSH), decrease of inflammatory mediators (TNFα), caspase 3 and increase of (NGF). Current results proved that Metformin has neuroprotective effect in addition to pregabalin that ameliorates vincristine induced peripheral neuropathy.
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