International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 9, Issue:6, June, 2020

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(6): 1246-1255

Antidiabetic and Antihypertensive Properties of Chymotrypsin Treated Cow Milk Casein
Santosh Kumar1*, SumanKumari2, Vipan Kumar3 and Deepak Kumar4
1MDETT Research Center, BAIF Development Research Foundation,Dharoli, Jind – 126113 (Haryana), India
2Dolphin PG Institute of Biomedical & Natural Sciences, Dehradun (Uttarakhand), India
3Department of Veterinary Microbiology, Khalsa College of Veterinary and Animal Science, Amritsar (Punjab), India
4Department of Pharmaceutical Chemistry, Dolphin PG Institute of Biomedical & Natural Sciences, Dehradun (Uttarakhand), India
*Corresponding author

Milk is known to contain a number of peptides fractions that affect metabolic responses. Casein being the most abundant milk protein, after enzymatic treatment generates peptide fragments which have unique ability to regulate the diabetic and hypertensive metabolic pathways in the biological system. Upon oral administration of bioactive peptides may affect the major body system-namely the cardiovascular, digestive, immune and nervous systems showing multiple biogenic effects such as antimicrobial, Immuno modulatory, antioxidative, antithromboic, antidiabetic and antihypertensive. In the present study, the peptide formulation derived from chymotrypsin treated cow milk casein was functionally studied for their antidiabetic (via α-amylase inhibition) and antihypertensive (via angiotensin converting enzyme inhibition) activity. The peptide content and their biogenic effects varies with the duration of enzymatic treatment thus depicting variable effects. Maximum antidiabetic effect was shown by bioactive derived after 3 hours of enzymatic treatment; while maximum antihypertensive effect was shown by bioactive derived after 6 hours of incubation with chymotrypsin. These metabolic effects of these unique peptide formulations were required to be explored for their targeted use as nutritional supplements for diabetic and hypertensive patients.

Keywords: Angiotensin converting enzyme(ACE), Amylase, Antihypertensive, Imunomodulation, Biogenic peptides

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How to cite this article:

Santosh Kumar, SumanKumari, Vipan Kumar and Deepak Kumar. 2020. Antidiabetic and Antihypertensive Properties of Chymotrypsin Treated Cow Milk Casein.Int.J.Curr.Microbiol.App.Sci. 9(6): 1246-1255. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.