National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Milk is known to contain a number of peptides fractions that affect metabolic responses. Casein being the most abundant milk protein, after enzymatic treatment generates peptide fragments which have unique ability to regulate the diabetic and hypertensive metabolic pathways in the biological system. Upon oral administration of bioactive peptides may affect the major body system-namely the cardiovascular, digestive, immune and nervous systems showing multiple biogenic effects such as antimicrobial, Immuno modulatory, antioxidative, antithromboic, antidiabetic and antihypertensive. In the present study, the peptide formulation derived from chymotrypsin treated cow milk casein was functionally studied for their antidiabetic (via α-amylase inhibition) and antihypertensive (via angiotensin converting enzyme inhibition) activity. The peptide content and their biogenic effects varies with the duration of enzymatic treatment thus depicting variable effects. Maximum antidiabetic effect was shown by bioactive derived after 3 hours of enzymatic treatment; while maximum antihypertensive effect was shown by bioactive derived after 6 hours of incubation with chymotrypsin. These metabolic effects of these unique peptide formulations were required to be explored for their targeted use as nutritional supplements for diabetic and hypertensive patients.
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