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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2016: 92.3
Index Copernicus ICI Journals Master List 2016 - IJCMAS--ICV 2016: 92.3
For more details click here
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(3): 1104-1108
DOI: https://doi.org/10.20546/ijcmas.2017.603.127


Effect of Meloxicam on Pharmacokinetics of Long Acting Moxifloxacin in Goats
Kumari Anjana1, S.K. Mody2, R.K. Nirala1* and Archana Kumari3
1Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna, India
2Department of Pharmacology and Toxicology, S.K. Nagar, Dantiwada Agricutural University, Gujrat, India
3Indian Council of Medical Research (ICMR), IITR Lucknow, India
*Corresponding author
Abstract:

Present study was conducted for pharmacokinetic interaction of long acting moxofloxacin (LA moxifloxacin) with meloxicam at the dose rate of 7.5 mg.kg-1 and 0.5 mg.kg-1 respectively following intramuscular (IM) administration. Peak plasma concentrations of drug were estimated by using HPLC florescence detector. The values of different pharmacokinetic parameter of long acting moxifloxacin along with viz., b and t1/2b were found to be 0.058 ± 0.004 h-1 and 12.297 ± 0.843 h. respectively. The mean value of Cmax was 1.56 mg.ml-1 and Tmax was 1.5 h. The average value for AUC and AUMC was 18.53 ± 0.754 mg.h.ml-1 and 251.183 ± 20.501 mg.h2.ml-1. The value of mean residence time (MRT) was 13.467 ± 0.726 h. The mean values of Vd(area) and Vd(ss) were 7.249 ± 0.645 and L.kg-1, respectively. The mean value for total body clearance (ClB) was 0. 408 ± 0.01 L.h-1.kg-1. Present investigation revealed that meloxicam interacts with Long Acting moxifloxacin.


Keywords: LA Moxifloxacin, Pharmacokinetic, Meloxicam, Goats.
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How to cite this article:

Kumari Anjana, S.K. Mody, R.K. Nirala and Archana Kumari. 2017. Effect of Meloxicam on Pharmacokinetics of Long Acting Moxifloxacin in GoatsInt.J.Curr.Microbiol.App.Sci. 6(3): 1104-1108. doi: https://doi.org/10.20546/ijcmas.2017.603.127