Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2017) [Effective from January 1, 2017]For more details click here
IJCMAS-UGC Approved List of Journal - For more detail click here
Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2015: 85.95
Index Copernicus ICI Journals Master List 2015 - IJCMAS--ICV 2015: 85.95
For more details click here
journals IJCMAS
See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2015: 85.95
NAAS RATING 2017: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(3): 868-877
DOI: https://doi.org/10.20546/ijcmas.2017.603.102


AmpC and Extended Spectrum Beta Lactamase Producing Isolates of E. coli, Klebsiella spp. and P. mirabilis in a Tertiary Care Center and
their Sensitivity to Other Antibiotics
V.L. Dudhat*, C.N. Chaudhari, Mahadevan Kumar, N. Grover, N.K. Das
Department of Microbiology, Microbiology and HIC, Sahyadri Speciality Labs, Pune, India
*Corresponding author
Abstract:

Enterobacteriaceae cause protean infections and are the common Gram negative isolates in a microbiology laboratory. Spectrum of multi-drug resistance includes AmpC, Extended spectrum beta lactamase and carbapenemase production with others. This was a cross sectional study to determine susceptibility pattern of AmpC and extended spectrum beta lactamase producing isolates against different antimicrobials. There was significant difference between the pure AmpC producing, pure ESBL producing, AmpC ESBL co-producing and AmpC ESBL non-producing isolates of E. coli, Klebsiella spp. and P. mirabilis regarding the resistance pattern against amoxycillin-clavulanate, piperacillin-tazobactam and co-trimoxazole for which the higher number of pure AmpC producers or AmpC ESBL co-producers were found to be resistant as compared to pure ESBL producers. In addition, there was significant difference in the resistance pattern against imipenem and chloramphenicol among pure AmpC producing, pure ESBL producing, AmpC ESBL co-producing and AmpC ESBL non-producing isolates of E. coli, sulfonamide in case of Klebsiella spp and imipenem in case of P. mirabilis isolates. The difference can be justified by the fact that the AmpC producers are not inhibited by the beta lactamase inhibitors like clavulanic acid.


Keywords: AmpC and Extended Spectrum Beta Lactamase
Download this article as Download

How to cite this article:

V.L. Dudhat, C.N. Chaudhari, Mahadevan Kumar, N. Grover, N.K. Das. 2017. AmpC and Extended Spectrum Beta Lactamase Producing Isolates of E. coli, Klebsiella spp. and P. mirabilis in a Tertiary Care Center and their Sensitivity to Other Antibiotics.Int.J.Curr.Microbiol.App.Sci. 6(3): 868-877. doi: https://doi.org/10.20546/ijcmas.2017.603.102