National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
At least two thirds of HCV infected cases would probably develop chronic HCV infections, and are thus at risk of developing liver cirrhosis and HCC. We investigated the sequence of hepatitis C virus RNA NS5A region in HCV-related HCC patients as well as in chronic HCV patients to highlight its potential pathogenic role, and investigated the usefulness of TGF-β1 and ICAM-1 as serological biomarkers in the diagnosis of HCV- related HCC. The results in this study indicated that 60% of group I (HCV-related HCC) and 23.3% of group II (chronic HCV) patients harbored a wild-type sequence of NS5A region with a significant difference between both groups. Moreover, there is significant increase in mean sequence identities in group I, compared to group II (p<0.001) and significant increase in mean number of mutations in NS5A, and ISDR regions in group II (p<0.001) compared to group I, and serum TGF-β1 and ICAM-1 levels in group I patients were significantly higher than those in group II patients (p<0.001). Conclusion: The wild type NS5A, particularly that of ISDR, is a significant marker for the development of HCV-related HCC. In addition, TGF-β1 and ICAM-1 are potential effective serological markers for the diagnosis of patients with HCV-related HCC.
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