International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:2, February, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 752-762

Markers of HCV-Related HCC in Egyptian Patients
Dina ElShennawy1, Nermeen Tayseer Aly Fouad1*, Hanaa Amer1, Amal T Abdel Moez2, Hanaa Fathey3, Marcel W Keddeas3 and Elewa AA3
1Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
*Corresponding author

At least two thirds of HCV infected cases would probably develop chronic HCV infections, and are thus at risk of developing liver cirrhosis and HCC. We investigated the sequence of hepatitis C virus RNA NS5A region in HCV-related HCC patients as well as in chronic HCV patients to highlight its potential pathogenic role, and investigated the usefulness of TGF-β1 and ICAM-1 as serological biomarkers in the diagnosis of  HCV- related HCC. The results in this study indicated that 60% of group I (HCV-related HCC) and 23.3% of group II (chronic HCV) patients harbored a wild-type sequence of NS5A region with a significant difference between both groups. Moreover, there is significant increase in mean sequence identities in group I, compared to group II (p<0.001) and significant increase in mean number of mutations in NS5A, and ISDR regions in group II (p<0.001) compared to group I, and serum TGF-β1 and ICAM-1 levels in group I patients were significantly higher than those in group II patients (p<0.001). Conclusion: The wild type NS5A, particularly that of ISDR, is a significant marker for the development of HCV-related HCC. In addition, TGF-β1 and ICAM-1 are potential effective serological markers for the diagnosis of patients with HCV-related HCC.

Keywords: HCV-related HCC,NS5A,ISDR,TGF-β1,ICAM-1

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How to cite this article:

Dina ElShennawy, Nermeen Tayseer Aly Fouad, Hanaa Amer, Amal T       Abdel Moez, Hanaa Fathey, Marcel W Keddeas and Elewa AA. 2016. Markers of HCV-Related HCC in Egyptian Patients.Int.J.Curr.Microbiol.App.Sci. 5(2): 752-762. doi:
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