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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 722-734
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.081


Analyses of Methanol Extracts of Two Marine Sponges, Spongia officinalis var. ceylonensis and Sigmadocia carnosa from Southwest Coast of India for their Bioactivities
A. Athira Krishnan1 and T. R. Keerthi2*
1School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India
2Microbial Biotechnology Laboratory, School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India
*Corresponding author
Abstract:

Marine sponges proved to be the richest source of bioactive compounds . In this study, methanol extracts of two marine sponges, Sigmadocia carnosa and Spongia officinalis var. ceylonensis were examined for their various bioactivities. The chemical constituents of these extracts were analyzed by routine phytochemical methods showed the presence of alkaloids, phenols, steroids, triterpenoids, reducing sugars and aromatic acids in both the sponge extracts. Antioxidant activity assayed using DPPH radical scavenging activity and total antioxidant activity indicated that both sponge extracts possessed antioxidant activity.  Immunomodulatory activity analyzed by calculating phagocytic index and Nitro Blue tetrazolium assay indicated that the extract of Sigmadocia was more immunomodulatory. Acetylcholinesterase inhibition assay revealed that Sigmadocia extract was more active. Anticancer effect of the methanolic extracts on colon cancer cell line HT-29 was confirmed by MTT assay. Thus the biomedical potential of the two species has been confirmed and further purification, bioactivity evaluation and chemical investigation of these extracts will yield potential bioactive molecules.


Keywords: Sigmadocia carnosa, Spongia officinalis var. ceylonensis, Acetylcholinesterase inhibition, Anticancer activity.
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How to cite this article:

Athira Krishnan, K. A.,  and Keerthi, T. R. 2016.  Analyses of Methanol Extracts of Two Marine Sponges, Spongia officinalis var. ceylonensis and Sigmadocia carnosa from Southwest Coast of India for their Bioactivities.Int.J.Curr.Microbiol.App.Sci. 5(2): 722-734. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.081