National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Marine sponges proved to be the richest source of bioactive compounds . In this study, methanol extracts of two marine sponges, Sigmadocia carnosa and Spongia officinalis var. ceylonensis were examined for their various bioactivities. The chemical constituents of these extracts were analyzed by routine phytochemical methods showed the presence of alkaloids, phenols, steroids, triterpenoids, reducing sugars and aromatic acids in both the sponge extracts. Antioxidant activity assayed using DPPH radical scavenging activity and total antioxidant activity indicated that both sponge extracts possessed antioxidant activity. Immunomodulatory activity analyzed by calculating phagocytic index and Nitro Blue tetrazolium assay indicated that the extract of Sigmadocia was more immunomodulatory. Acetylcholinesterase inhibition assay revealed that Sigmadocia extract was more active. Anticancer effect of the methanolic extracts on colon cancer cell line HT-29 was confirmed by MTT assay. Thus the biomedical potential of the two species has been confirmed and further purification, bioactivity evaluation and chemical investigation of these extracts will yield potential bioactive molecules.
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