National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The transition metals are a group of metals that are found in the middle of the periodic table. The alkaline earth metals, beginning with beryllium are to the left and the boron group elements are to the right are termed as "transition element". There are more transition metals than any other groups in the periodic table. Transition metals have several general properties. They are harder and less reactive than the alkaline earth metals. They are also harder than the post transition metals. They make colorful chemical compounds with other elements. Most of them have more than one oxidation state. Like other metals, they are electrical conductors. Some of the transition metals are necessary for human health, such as iron, zinc, and chromium. Other elements in the transition metals can be harmful to our body, like cadmium and mercury. Other elements like gold or silver do not harm or help us. Only a few of the transition metals are colored; most of them are silver-gray or silver-bluish. The oxidation activity of transition metals led to the recent development of drugs which are based on metals and are considered to be potential for pharmacological and therapeutic applications. This review emphasizes on preclinical pharmacological screenings like anti-microbial, anti-inflammatory and anti-tumor action of synthetic transition metal complexes. It concentrates primarily on a limited number of first row transition metal complexes and traces the pharmacological applications of these coordination compounds. In the first part, the nitrogen, oxygen and sulfur donor ligands chelating to transition metals used in metallo drugs are described. The second part describes the pre-clinical screenings viz., anti-microbial, anti-inflammatory and anti-tumor responses of the above coordination compounds incorporating these nitrogen, oxygen and sulfur donor ligands. This survey encourages further research in this field for biomedical industry.
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