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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2020.9(2): 1001-1010
DOI: https://doi.org/10.20546/ijcmas.2020.902.117


Hepatoprotective Effect of Andrographis paniculata against Oxidative Damage Caused by Cisplatin in Rats
T. Rajendrakumar1*, Suguna Rao1, M. L. Satyanarayana1, H. D. Narayanaswamy1, S. M. Byregowda2 and N. B. Shridhar3
1Department of Veterinary Pathology, Veterinary College, KVAFSU, Hebbal, Bangalore-560024, India
2Institute of Animal Health and Veterinary Biologicals, KVAFSU, Bangalore, India
3Asscociate Professor, Department of Veterinary Pharmacology, Veterinary College, Vinobanagar, Shimogga-577204, India
*Corresponding author
Abstract:

The role of ethanolic extract of Andrographis paniculata (AP), in preventing cisplatin (CP) induced oxidative damage in rat liver was studied. The study included 60 Wistar albino rats were divided into 12 rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP 15 days prior to CP administration and followed by AP treatment for 45 days. Rats in group V were administered with CP and concurrently treated with AP extract at 500mg/kg by oral gavaging for 45 days. The liver samples collected at 7th, 14th, 28th, and 45th day of the study were subjected for estimation of endogenous antioxidant enzymes (SOD, CAT and GPx) and malondialdehyde (MDA). Significant decrease (P<0.05) in the levels of antioxidant enzymes and increase in MDA levels were recorded in CP treatment group. The AP treatment groups revealed a significant recovery (P<0.05) all enzymes and decrease in MDA levels which suggested that AP has a good antioxidant effect and could be effectively used for prevention of toxic side effects of CP.


Keywords: Cisplatin, antioxidants, hepatotoxicity, Andrographis paniculata, Malondialdehyde
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How to cite this article:

Rajendrakumar. T., Suguna Rao, M. L. Satyanarayana, H. D. Narayanaswamy, S. M. Byregowda and Shridhar. N.B. 2020. Hepatoprotective Effect of Andrographis paniculata against Oxidative Damage Caused by Cisplatin in Rats.Int.J.Curr.Microbiol.App.Sci. 9(2): 1001-1010. doi: https://doi.org/10.20546/ijcmas.2020.902.117