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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(2): 1687-1693
DOI: http://dx.doi.org/10.20546/ijcmas.2017.602.188


Serum Cystatin C Compared to Serum Creatinine as an  Early Marker of Renal Failure
M.Sahoora Beegum1*, Vishnu Mohan2, C.P.Kailasanathan3 and Edwin Emperor Cyrilraj4
1Department of Biochemistry, Government Medical College, Thiruvananthapuram, India
2Kerala Health Services, Kannur, India
3Department of Biochemistry, Indira Gandhi Government Medical College, Thiruvananthapuram, India
4Department of Plastic and Reconstructive Surgery, Kanyakumari Government Medical College, Asaripallam, Nagercoil, Tamilnadu, India
*Corresponding author
Abstract:

The main aim of this study whether serum cystatin C can detect early changes in development of acute kidney injury compared to serum creatinine in critically ill patients and to study the confounding factors that normally can interfere in the analysis of serum creatinine. Serum cystatin C showed a faster increase in critically ill patients who were in the early stages of acute kidney injury compared to serum creatinine. Serum cystatin C showed superior sensitivity in adolescents, adults and in aged peoples compared to serum creatinine in detecting acute kidney injury. Cystatin showed better sensitivity in classifying patients having acute kidney injury into Risk, Injury and Failure categories compared to creatinine. Cystatin C showed excellent diagnostic accuracy in detecting patients having renal injury than creatinine. Using cystatin C measurements, we can diagnose acute kidney injury early and start prompt intervention to prevent adverse outcomes, because such intervention drastically improves the outcomes of acute kidney injury. Cystatin C may be considered as an alternative and more accurate serum marker than serum creatinine in early detection of impairment of GFR. Future studies should focus on GFR staging by standardizing the definition of control groups and the cut-off values for Cystatin C and Creatinine, in order to provide the diagnostic basis for the clinical application of Cystatin C and Serum Creatinine for estimating GFR.


Keywords: Renal Failure, Acute kidney injury, Serum Cystatin C, Serum Creatinine
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How to cite this article:

Sahoora Beegum, M., Vishnu Mohan, Kailasanathan, C.P., Edwin Emperor Cyrilraj. 2017. Serum Cystatin C Compared to Serum Creatinine as an Early Marker of Renal Failure.Int.J.Curr.Microbiol.App.Sci. 6(2): 1687-1693. doi: http://dx.doi.org/10.20546/ijcmas.2017.602.188