Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(12): 2623-2629
DOI: https://doi.org/10.20546/ijcmas.2019.812.306


Antidepressant Potentials of Aqueous Extract of Voacanga africana stept. ex Eliot (Apocynaceae) Stem Bark
Tunde A. Owolabi1,2*, K.C. Ezenwa1, E. Amodu1, O.C. Iyoriobhe1, P.C. Okubor3, D.P. Aigbe1,4 and J.I. Okogun1,4
1Research Unit, Paxherbal Clinic and Research Laboratories, Edo state, Nigeria
2Pharmacognosy department, University of Benin, Benin City, Edo State, Nigeria
3Department of Biology, College of Education, Agbor, Delta state, Nigeria
4Department of Botany, Ambrose Alli University, Ekpoma, Edo State
*Corresponding author
Abstract:

A large number of the world’s population suffer from depression and anxieties at some points in their life time, the sufferers are however sceptical about the available orthodox drugs largely because of side effects, cost and availability. This present study was aimed at evaluating the antidepressant potentials of Voacanga africana to query its ethno medicinal claim. The extract of the stem-bark of the plant was screened for its phytochemical composition, and antidepressant potentials assessed using forced swimming test (FST) and tail suspension test (TST). The results revealed presence of abundant alkaloids, but traces of saponin, terpenoid, cardiac glycosides with a meaningful antidepressant potentials at doses of 100 and 200 mg/kg by reducing the immobility duration in FST (46.19±1.212and 23.96±1.14 compared to the negative control 79.06± 0.16 and positive control~imipramine 24.13±0.405), also increasing the swimming duration from 159±0.416 of the negative control to 187.91±0.516 and 217.24±1.132 seconds respectively. Similar trend was observed in the TST, where the immobility duration was reduced from 183.207± 5.157 (negative control) to 98.62± 0.347 and 75.51± 1.366for 100 and 200 mg/kg test drug compared to 62.77± 0.426 secs (positive control). The ethno-medicinal claim of this plant is hereby justified.


Keywords: Voacanga africana, Antidepressant, Forced swim test, Tail suspension test, Phytochemicals
Download this article as Download

How to cite this article:

Tunde A. Owolabi, K.C. Ezenwa, E. Amodu, O.C. Iyoriobhe, P.C. Okubor, D.P. Aigbe and Okogun, J.I. 2019. Antidepressant Potentials of Aqueous Extract of Voacanga africana stept. ex Eliot (Apocynaceae) Stem Bark.Int.J.Curr.Microbiol.App.Sci. 8(12): 2623-2629. doi: https://doi.org/10.20546/ijcmas.2019.812.306