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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(11): 1979-1985
DOI: https://doi.org/10.20546/ijcmas.2019.811.231


Seroprevalence of Human Cytomegalovirus Infection among Patients undergoing Chronic Hemodialysis in Benghazi, Libya
Farag Bleiblo1,4*, Abdelhakim Eljaki1, Khaled Elwaheishi1, Mabroka Aljlale1, Ata Alfalah1, Rabea Alghazal2 and Mohammed Abraheem3
1Department of Microbiology, Faculty of Science, University of Benghazi, Libya
2 Immunology &Virology Laboratory, Benghazi Children Hospital, Libya
3 Department of Botany, Faculty of Arts and Science/Alkufra, University of Benghazi, Libya
4Department of Chemistry and Biochemistry and the Biomolecular Sciences Programme, LaurentianUniversity, Sudbury, ON, Canada, P3E 2C6
*Corresponding author
Abstract:

Human cytomegalovirus (HCMV) is a prominent opportunistic infectious agent causes severe and fatal diseases in immune compromised individuals including patients undergoing hemodialysis. Although the impact of HCMV infection in general population and patients at particular health care institutions are well documented in several regions, the seroepidemiologic data and overall awareness of disease risk of HCMV infection remain largely poor in Libya. Therefore, this study was undertaken to derive chronic hemodialysis-based estimates of HCMV prevalence. A total of 102 subjects admitted to the hemodialysis unit at Nephrology Center of Benghazi/Libya were enrolled in this study and investigated for CMV IgM and IgG antibodies as well as CMV pp65 antigenemia tests. The overall seropositivity for IgG antibodies (% 26.47) was higher than those of IgM antibodies (% 21.56) and pp65 (% 17.64). CMV-IgG was detected in a higher rate in females than that in males (% 27.58% and % 26.02 respectively). Similarly, the seroprevalence of CMV-IgM were also much higher in females (% 48.27) than that in male patients (% 10.95). We also noticed a higher proportion of females were seropositive for CMV-pp65 (% 20.68) than males (% 16.43). However, there was no significant difference in the seroprevalence rates of CMV infection based on gender. According to age, a progressive increase in seropositivity of CMV was observed in all three tests performed on hemodialysis patients. However, the age groups were not significantly associated with CMV prevalence. In contrast, only 2 (% 1.96) patients were shown to be positive for all three performed assays indicating a recurrent infection. In addition to the clinical significance of our findings for the management of CMV infection in hemodialysis patients, CMV infections in this setting may also improve our understanding of the viral pathogenesis.


Keywords: CMV, Hemodialysis, Seroprevalence, CMV-IgG, CMV-IgM, CMV-pp65
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How to cite this article:

Farag Bleiblo, Abdelhakim Eljaki, Khaled Elwaheishi, Mabroka Aljlale, Ata Alfalah, Rabea Alghazal and Mohammed Abraheem. 2019. Seroprevalence of Human Cytomegalovirus Infection among Patients undergoing Chronic Hemodialysis in Benghazi, Libya.Int.J.Curr.Microbiol.App.Sci. 8(11): 1979-1985. doi: https://doi.org/10.20546/ijcmas.2019.811.231