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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(2): 1163-1172
DOI: http://dx.doi.org/10.20546/ijcmas.2017.602.131


Effect of Epidural Ketamine in Combination with Opioids on Haemodyanamics and Electrocardiograph in Dogs
R.P. Ram1, A.K. Sharma1*, A.K. Anandmay1 and Raju Prasad2
1Department of Veterinary Surgery and Radiology, College of Veterinary Science and Animal Husbandry, Birsa Agricultural University, Kanke, Ranchi-834006, India
2Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Birsa Agricultural University, Kanke, Ranchi-834006, India
*Corresponding author
Abstract:

The objective of this study is to find out the effect of ketamine in combination of opioids on haemodynamics and electrocardiograph in dogs. The ketamine hydrochloride at 3mg/kg bwt was administered epidurally at lumbosacrcal space in group I, whereas buprenorphine at 0.005 mg/kgbwt, pentazocine at 0.3 mg/kg bwt and meperidine hydrochloride (at 1 mg/kgbwt were given epidurally in combination with ketamine hydrochloride in group II, III and IV, respectively. To accomplish epidural block, an 18-gauge 3.5 cm hypodermic needle was inserted percutaneously at the prepared site into the epidural space to inject analgesic agent. Haemodynamic and electrocardiographic changes were recorded before and at the time intervals of 5, 15, 30, 60 and minutes of ketamine administration. Haemodyanamic parameters viz. heart rate, systolic arterial pressure, diastolic arterial pressure and mean arterial pressure showed a significant higher (P<0.05) value at initial intervals of observation, thereafter, the values revealed a decreasing trends and returned to base line value by the end of observation. Shortening of PR, R.R. and QT intervals were recorded at 5 min up to 30 min. in all the groups. The QRS complex did not show significant variation among and between groups. In conclusion, ketamine in combination of buprenorphine, pentazocine and meperidine as epidural anaesthesia in dogs was found to be effective and produces reversible changes on haemodynamics and Electrocardiograph.


Keywords: Dogs, Epidural anaesthesia, Haemodynamics, Electrocardio-graphic changes.
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How to cite this article:

Ram, R.P., A.K. Sharma, A.K. Anandmay and Raju Prasad. 2017. Effect of Epidural Ketamine in Combination with Opioids on Haemodyanamics and Electrocardiograph in Dogs.Int.J.Curr.Microbiol.App.Sci. 6(2): 1163-1172. doi: http://dx.doi.org/10.20546/ijcmas.2017.602.131