International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:2, February, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 598-607

Bacteriological Profile of Septicaemia and Extended Spectrum Beta Lactamases Production in Multi Drug Resistant Strains
Ruby Naz1, Mohammad Khalid Farooqui2*, Ruchi Girotra1 and A. K. Malik1

1Department of Microbiology, SHKM GMC Mewat, Haryana, India

2Department of ENT, SHKM GMC Mewat, Haryana, India

*Corresponding author

Blood streams infections are important cause of sever morbidity and mortality of patients. The study aimed to find out aerobic bacteriological profile and evaluate emergence of ESBL among multi drug resistant strains. 571 bacterial isolates were subjected to antibiotic susceptibility test for common antibiotics used to treat septicaemia and double disc and Amp C disc test for detection of ESBL and Amp C β lactamases among multidrug resistant strains. In our study maximum patients were from paediatric ward, female patients were more than male but difference is insignificant. There were Pseudomonas (19%), Staphylococcus aureus (12.9%), Klebsiella (12.1%), E. coli (11%), CONS (11%), Enterobacter (8.8%), Citrobacter (8.2%), Acinetobacter (7%), Candida (4%), Enterococcus (2.4%), and salmonella typhi (1.9%). Gram positive cocci were highly sensitive to vancomycin and teicoplanin and Gram negative bacilli were highly sensitive to Imepenem and quinilones. 21.1% of Enterobacteriaceae produced ESBL, 6.4% produced Amp C β lactamase and 6.3% produced both type of β lactamases.  Two isolates of pseudomonas were MBL positive. 23% organism were multi drug resistant (MDR) in all isolates. There was no PDR found in our study. In gram positive cocci 53% were MRSA and 43% were MRCoNS. Significant difference found between antibiotic susceptibility of ESBL and non ESBL strain. Data of our study provided much needed information on prevalence of antimicrobial resistance amongst pathogens causing blood stream infections in Mewat region. Multidrug resistant organism can result in treatment failure. Therefore it is recommended that any ESBL producing organism according to national committee for clinical laboratory standards (NCCLS) can be reported as resistant to all extended spectrum β lactam antibiotics regardless of susceptibility test results

Keywords: Septicaemia, Extended Spectrum Beta Lactamases, Multi Drug Resistant Strains

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Ruby Naz, Mohammad Khalid Farooqui, Ruchi Girotra and A. K. Malik. 2016. Bacteriological Profile of Septicaemia and Extended Spectrum Beta Lactamases Production in Multi Drug Resistant Strains.Int.J.Curr.Microbiol.App.Sci. 5(2): 598-607. doi:
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