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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(10): 1486-1493
DOI: https://doi.org/10.20546/ijcmas.2019.810.174


Effect of Glyphosate (GLP) Induced Toxicity on Body Weights and Gross Pathology: Ameliorative Effect of Ascorbic Acid (AA) in Wistar Rats
M. Lakshmi Namratha1, M. Lakshman1*, M. Jeevanalatha2 and B. Anil Kumar3

1Department of Veterinary Pathology, College of Veterinary Science,Rajendranagar, Hyderabad-500030, India
2Department of Veterinary Pathology, College of Veterinary Science, Mamnoor-506166, India
3Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad-500030, India


*Corresponding author
Abstract:

The aim of this study was to determine the body weight changes and gross pathological alterations induced by glyphosate exposure in male albino Wistar rats and its amelioration with Ascorbic Acid. Forty eight (48) adult male albino Wistar rats were used for this study. The experiment was carried out for 21 days. The animals were randomized into 4 groups with twelve (12) animals in each. Group 1 - control, group 2 - GLP (@500 mg/kg b.wt), group 3 - AA (@250 mg/kg b.wt) and group 4 - GLP+AA (@500 mg/kg b.wt + 250mg/kg b.wt). The treatment regimens were administered by oral gavage once daily for three weeks. Individual body weights of all the rats were recorded soon after arrival and subsequently on 7th, 14th and 21st day of experiment to study the body weight gains. A significant (P<0.05) reduction in the body weights were recorded in glyphosate treated rats compared to the control rats. On necropsy examination, severe congestion of liver, kidneys and testes and atrophy of kidneys and testicles were recorded in glyphosate treated rats.


Keywords: Glyphosate, Albino Wistar rats, Body weights Ascorbic Acid and oral gavage
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How to cite this article:

Lakshmi Namratha, M., M. Lakshman, M. Jeevanalatha and Anil Kumar, B. 2019. Effect of Glyphosate (GLP) Induced Toxicity on Body Weights and Gross Pathology: Ameliorative Effect of Ascorbic Acid (AA) in Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 8(10): 1486-1493. doi: https://doi.org/10.20546/ijcmas.2019.810.174