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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 540-546
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.061


Understanding of Quorum – Sensing: A Possible Solution for Drug Resistance in Bacteria
 
Seema Bose1* and Atindra Krishna Ghosh2
Department of Microbiology, Rural medical college, Pravara Institute of Medical Sciences,
Loni, Maharashtra, India
2 Department of Medicine, Rural Medical College, Pravara Institute of Medical Sciences, Loni, Maharashtra, India
*Corresponding author
Abstract:

Quorum – sensing (QS) enables bacteria to establish cell- to – cell communication. Few among many QS molecules in bacteria are peptide and acylated homoserine lactones. QS regulate genes that code for invasion, spread and other virulence factors. It also takes part in biofilm formation. QS mediate via small signaling molecules known as auto inducers. Quorum – quenching inhibits QS. Several chemical compounds and enzymes mediate inhibition of QS, such as, lactonases, acylases and oxydoreductases. Other than these, there are some non-enzymatic methods for quorum quenching. Blocking of QS by QS inhibition (QSI) may play an important role to disrupt biofilm formation in a device - associated infection and chronic drug   resistant infection. More researches are required in this area related with QS and QSI.


Keywords: Quorum,sensing Quorum, quenching Gene, regulator
 
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How to cite this article:

Seema Bose and Atindra Krishna Ghosh. 2016. Understanding of Quorum – Sensing: A Possible Solution for Drug Resistance in BacteriaInt.J.Curr.Microbiol.App.Sci. 5(2): 540-546. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.061