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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2019) [Effective from January 1, 2019]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 511-522
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.058


Synthesis, Characterization and Polymerization of 1,3,4- Oxadiazole Derivatives of Amoxicillin and Evaluation Antibacterial Activities
Entesar, Obeed. AL-Tamimi1 and Khalida, Ali.Thejeel2*
1Department of Chemistry, College of Science, University of Baghdad, Iraq
2Department of Pharmaceutical Chemistry, College of Pharmacy, University of AL-Mustansriah, Iraq
*Corresponding author
Abstract:

A new series of 1,3,4-oxadiazoles, have been synthesized from amoxicillin on treatment with various chemicals, the prepared 1,3,4-oxadaizoles derivatives(9-13) reacted with acryloyl chloride to prepared acryl monomers (14-18) that polymerized to acryl polymers of amoxicillin derivatives (19-23). The structures of compounds (2-23) have been elucidated by FT-IR and 1HNMR, furthermore some compounds (9-13) and (19-23) were screened for in vitro antibacterial activity against gram positive and gram negative bacteria. The  compounds show inhibitory action against test organism


Keywords: Amoxicillin, Acryl monomers, Antibacterial activity.
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How to cite this article:

Entesar, Obeed. AL-Tamimi and Khalida, Ali.Thejeel. 2016. Synthesis, Characterization and Polymerization of 1,3,4- Oxadiazole Derivatives of Amoxicillin and Evaluation Antibacterial ActivitiesInt.J.Curr.Microbiol.App.Sci. 5(2): 511-522. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.058