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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 475-482
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.053


Hypotensive Effect of an Aqueous Extract from Heliotropium indicum Linn. 1753 (Boraginaceae)
ZAHOUI Ouga Stanislas*, NENE BI Semi Anthelme, SORO Tianga Yaya and TRAORE Flavien
Department of Physiology, U.F.R Biosciences, University Felix Houphouet-Boigny, 22 B.P. 582 Abidjan 22, Côte d’Ivoire
*Corresponding author
Abstract:

The use of Heliotropium indicum for the treatment of various conditions has been demonstrated by many précedants works. The aim of this present study was to demonstrate the hypotensive potential of this plant. Starting from an animal model, we were able to show that this aqueous extract at doses ranging  between 3.51x10-3 and 3.75x10-2 g/kg bw, induced a sustained hypotension (dose-dependent) similar to that caused by acetylcholine (Ach) at doses ranging from 5.6x10-7 g/kg body weight and 5.5x10-4 g/kg body weight in rabbits.The study of the interaction between Adrenaline (Adr), a hypertensive reference molecule to 2.5x10-5 g/kg bw and aqueous extract of Heliotropium indicum (AEH) showed that the extract has significantly reduced the hypertension induced by Adr.These results indicated that the aqueous Heliotropium indicum extract had a hypotensive potential. The traditional use of this plant to treat arterial hypertension was justified.


Keywords: Heliotropium indicum, Hypotensive potential, Hypertensive effect
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How to cite this article:

ZAHOUI Ouga Stanislas, NENE BI Semi Anthelme, SORO Tianga Yaya and TRAORE Flavien. 2016. Hypotensive Effect of an Aqueous Extract from Heliotropium indicum Linn. 1753 (Boraginaceae).Int.J.Curr.Microbiol.App.Sci. 5(2): 475-482. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.053