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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(7): 350-358
DOI: https://doi.org/10.20546/ijcmas.2019.807.043


Is Smoothelin Useful for Detection of Muscularis Propria Invasion in Urinary Bladder Carcinoma Cases?
Nehal Abd El-Ghaffar Heabah*, Mohammed Farid Aref, Mohamed Alaa Mokhtar, Mohamed Moustafa Shareef and Ahlam Mohamed Abo El-Enain
Pathology Department, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Urinary bladder carcinoma is a common urologic malignancy, particularly in males. We studied the role of smoothelin (a cytoskeleton protein) as a diagnostic marker for muscularis propria invasion, differentiating it from the muscularis mucosae for proper staging in urinary bladder carcinoma patients. Paraffin blocks from 85 cases of bladder carcinoma: 69 urothelial carcinoma cases, 10 squamous cell carcinoma cases, 5 adenocarcinoma cases and one case neuroendocrine small cell carcinoma, were stained by smoothelin immunohistochemical marker. Smoothelin proved an important diagnostic utility, allowing distinction of the muscularis propria MP (positive smoothelin expression) from the muscularis mucosa MM (negative smoothelin expression). The sensitivity and specificity of smoothelin in detecting MP invasion in the current study was 100%. It is important to use smoothelin immunohistochemistry as a routine in all cases of TURBT specimens for accurate staging and subsequent optimal patient management.


Keywords: Urinary bladder carcinoma, Smoothelin, Muscularis propris invasion
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How to cite this article:

Nehal Abd El-Ghaffar Heabah, Mohammed Farid Aref, Mohamed Alaa Mokhtar, Mohamed Moustafa Shareef and Ahlam Mohamed Abo El-Enain. 2019. Is Smoothelin Useful for Detection of Muscularis Propria Invasion in Urinary Bladder Carcinoma Cases?Int.J.Curr.Microbiol.App.Sci. 8(7): 350-358. doi: https://doi.org/10.20546/ijcmas.2019.807.043