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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 609-619
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.074


Is a Retrovirus (XMRV) Risk Factor for Prostate Cancer in Indian Population

Kapil Bandil1,2, Anoop Kumar1, Atika Dogra3, Sudhir K. Rawal4, D.C. Doval5, Anil K. Varshney6 and Mausumi Bharadwaj1,2*

1Division of Molecular Genetics & Biochemistry; Institute of Cytology & Preventive Oncology (ICMR), I-7, Sector-39, Noida, India
2Utter Pradesh Technical University, Lucknow, U.P. India
3Research Department , 4Surgical Gynae Uro-Oncology, 5Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, Rohini, New Delhi, India
6R.G. Stone Urology & Laparoscopy Hospital, New Delhi, India
*Corresponding author
Abstract:

Presently, the known gamma-retroviruses, Xenotropic Murine Leukemia virus (MLV) -related Virus (XMRV) is imminent as a cancer causing infectious virus in prostate cancer. This study has been designed on retrovirus (XMRV) infection in Indian PCa patient and its co-relation with clinical pathological and demographic parameters of prostate cancer cases and Benign Prostate hyperplasia (BPH) as controls.  A total of 235 prostate samples including 105 confirmed prostate cancer cases and 130 benign prostate hyperplasia (BPH) as controls were analyzed for XMRV infection. We have used Nested –PCR method for XMRV detection followed by sequencing. Statistical analysis was done by Graphpad Instat version 3.3 for co-relation between XMRV status and clinical pathological parameters of prostate cancer cases and BPH controls. Out of 235 prostate samples, XMRV was detected 5.4% (7/130) in BPH tissue samples and 7.6% (8/105) in PCa tissue samples. Patients with higher PSA level were found to prone for XMRV infection in both PCa as well as BPH samples with non significant statistical correlation (p˃0.05). We found no significant correlation with other clinical parameter like Gleason score (p=0.72), histological grading (p=0.82) and tumor stages I-IV (p=0.31). This study does not support the evidence of XMRV infection in prostate cancer initiation and development in Indian population. Clearly, decision of this discrepancy will require more information and investigation with larger sample size.


Keywords: Prostate cancer, BPH, XMRV infection,Xenotropic Murine Leukemia virus (MLV)
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How to cite this article:

Kapil Bandil, Anoop Kumar, Atika Dogra, Sudhir K. Rawal, D.C. Doval, Anil K. Varshney, Mausumi Bharadwaj. 2017. Is a Retrovirus (XMRV) Risk Factor for Prostate Cancer in Indian Population.Int.J.Curr.Microbiol.App.Sci. 6(1): 609-619. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.074