International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:2, February, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 49-458

Study of the Impact of Hepatitis D Virus Infection on Chronic Hepatitis B Virus Patients in Egypt
Mohamed Abdel-Hamid Ahmed1, MostafaSaleh Abdel-Motaleb Sheemy2, Nagwa Sedky3, Gamal Esmat4 and Azza Abdul-Azim Gomaa5*
1Medical Microbiology and Immunology Department, Faculty of Medicine,
Minia University, Egypt
2Medical Microbiology and Immunology, Department, Faculty of Medicine,
Beni-Suef University, Egypt
3Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Egypt
4Tropical Medicine, Faculty of Medicine, Cairo University, Egypt
5Medical Microbiology and Immunology Department, Faculty of Medicine, Beni-Suef University, Egypt
*Corresponding author

Hepatitis D virus (HDV) is a defectivevirus thatrequires the presence of hepatitis B virus (HBV) for infection. It has been estimated that approximately 5% of the global hepatitis B surface antigen (HBsAg) carriers are also co-infected with HDV, leading to a total of 10–15 million HDV carriers worldwide. In the current study, we investigated anti-HDV seroprevalance, epidemiological features and effect of HDV on HBV morbidity and presence ofHBe antigen markers among 216 HBsAg seropositive patients recruited from four hospitals in Egypt between October 2009 and October 2011. Anti-HDV assay was performed by enzyme immunoassay (EIA). Then, the HDV seropositive patients were further investigated for HBe antigen and antibody, HBV DNA and HBV genotyping.Out of 216 HBsAg positive patients, 32 (14.8%) were anti-HDV positive. This study confirmed a declining trend in the prevalence of HDV infection in Egypt. A suppressive effect of HDV on HBV replication was suggested from the lower rate of detection of HBeAg (3.13%), which is indirectly proportional to viral replication, and the higher rate of detection of HBeAb (75%) in anti-HDV positive patients.

Keywords: HDV, HBV, HBsAg, Viral replication, HBeAg, HBeAb, genotyping.

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How to cite this article:

Mohamed Abdel-Hamid Ahmed, MostafaSaleh Abdel-Motaleb Sheemy, Nagwa Sedky, Gamal Esmat and Azza Abdul-Azim Gomaa. 2016. Study of the Impact of Hepatitis D Virus Infection on Chronic Hepatitis B Virus Patients in EgyptInt.J.Curr.Microbiol.App.Sci. 5(2): 49-458. doi:
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