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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(1): 484-491
DOI: http://dx.doi.org/10.20546/ijcmas.2017.601.057


Study the Utility of Cryptococcal Latex Agglutination Test in HIV-Positive and Negative Patients Suspected of having Cryptococcal meningitis and Compare with India Ink Preparation and Fungal Culture
Susheela Chaurasia, Ashwini Waghmare* and Ameeta Joshi
Department of Microbiology, Grant Medical College, Mumbai, India
*Corresponding author
Abstract:

Among the non-tuberculous causes of meningitis, cryptococcal meningitis tops the list with prevalence around five percent in India. The present study was carried out to compare latex agglutination test with India Ink Preparation and fungal culture admitted to a tertiary care hospital. The samples for the study were received from all age groups of HIV-positive patients suspected of having meningitis admitted to either medicine or paediatric ward and HIV-negative patients with signs and symptoms of meningitis were taken as control group. Out of 1,224 HIV-positive patients, 224 were clinically suspected cases of meningitis. Antigen detection test was done on 160 patients irrespective of their HIV status. Of these, 22 cases were found to be positive for the cryptococcal antigen detection test; only 18 cases were culture positive and the remaining four (2.82%) were culture negative. Majority (18, 81.8%) of the HIV-positive patients with cryptococcal meningitis, had CD4+ T-lymphocyte cell count < 200 cells/ µl. It was observed that cryptococcal antigen detection test was more sensitive (100%) as compared to culture (81.8%) and India ink preparation (68.2%).


Keywords: Cryptococcal meningitis, fungal culture, HIV Positive, Cryptococcal antigen, India ink preparation.
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How to cite this article:

Susheela Chaurasia, Ashwini Waghmare and Ameeta Joshi. 2017. Study the Utility of Cryptococcal Latex Agglutination Test in HIV-Positive and Negative Patients Suspected of having Cryptococcal meningitis and Compare with India Ink Preparation and Fungal Culture.Int.J.Curr.Microbiol.App.Sci. 6(1): 484-491. doi: http://dx.doi.org/10.20546/ijcmas.2017.601.057