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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(5): 1791-1795
DOI: https://doi.org/10.20546/ijcmas.2019.805.207


Histological Study on the Changes of Elastic Fibers in Localized Scleroderma Model in Thin Skin of Adult Male Albino Rat and the Possible Curative Role of Bone Marrow-Derived Mesenchymal Stem Cells
Maram M. Elkelany*, Amira A. Kassab, Amal A. Abd-Elhafez, Amany M. Mousa and Thoraya A. El-deeb
Histology Department, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Scleroderma is an autoimmune disease manifested by painful digital ulcers, joint contracture and skin thickening. Bone marrow-derived mesenchymal stem cells (BM-MSCs) have become a recent focus of interest in tissue regeneration. The aim of this work was to study the changes of elastic fibers in localized scleroderma model in thin skin of adult male albino rat and the possible curative role of bone marrow-derived mesenchymal stem cells. 45 rats divided into control group included 15 rats, scleroderma-model group were injected with bleomycin subcutaneously in the mid back for 4 consecutive weeks, media treated group received media one day after the last bleomycin injection, stem cell treated group received suspended BM-MSCs (2.5×106) one day after the last bleomycin injection. Scleroderma-model and media treated groups showed black thick elastic fibers in both papillary and reticular dermis using Verhoeff’s method. However, stem cell group showed black thin elastic fibers in both papillary and reticular dermis. From this study, it could be concluded that bleomycin induced structural changes in the dermis of thin skin that was ameliorated by BM-MSCs. So, it is recommended to use mesenchymal stem cells (MSCs) in scleroderma treatment.


Keywords: Elastic fibers, Scleroderma model, Albino rat, Mesenchymal stem cells
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How to cite this article:

Maram M. Elkelany, Amira A. Kassab, Amal A. Abd-Elhafez, Amany M. Mousa and Thoraya A. El-deeb. 2019. Histological Study on the Changes of Elastic Fibers in Localized Scleroderma Model in Thin Skin of Adult Male Albino Rat and the Possible Curative Role of Bone Marrow-Derived Mesenchymal Stem Cells.Int.J.Curr.Microbiol.App.Sci. 8(5): 1791-1795. doi: https://doi.org/10.20546/ijcmas.2019.805.207