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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 2494-2504
DOI: https://doi.org/10.20546/ijcmas.2019.804.290


Bacterial DNA Adenine Methyltransferase as a Novel Drug Target for Antibiotics: Current Status and Future Drug Discovery Challenges
Umairah Natasya Mohd Omeershffudin and Suresh Kumar*
Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management & Science University, Shah Alam, Selangor, Darul Ehsan, Malaysia
*Corresponding author
Abstract:

Antibiotic resistance and the particular emergence of multi - resistant bacterial strains are clinically relevant issue involving serious threats to public health worldwide. DNA methylation, which changes the affinity and interaction of regulatory proteins with DNA, is an epigenetic mechanism that regulates numerous bacterial physiological processes, including chromosome replication, DNA segregation, mismatch repair, transposition and transcription. DNA adenine methylase (Dam), which methylates N-6 of adenine in the GATC sequence, plays a key role in the gene expression of bacterial virulence. Current antibiotic – resistant studies were gradually associated with adenine methyltransferase (DAM), an inhibitor of DNA, which plays a key role in the pathogenesis of bacteria. DAM is essential in regulating the replication and gene expression of the bacterium. The emergence of DAM in epigenetics studies facilitates the drug discovery of this multi-resistant pathogen. The goal of the review is to examine the status and challenges of the antibiotic resistance study in relation to bacterial DNA Adenine Methyltransferase.


Keywords: DNA Adenine Methyltransferase, Drug target, Antibiotics, Drug discovery
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How to cite this article:

Umairah Natasya Mohd Omeershffudin and Suresh Kumar. 2019. Bacterial DNA Adenine Methyltransferase as a Novel Drug Target for Antibiotics: Current Status and Future Drug Discovery Challenges.Int.J.Curr.Microbiol.App.Sci. 8(4): 2494-2504. doi: https://doi.org/10.20546/ijcmas.2019.804.290