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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 614-624
DOI: https://doi.org/10.20546/ijcmas.2019.804.067


Optimization of Nutrients and Process Parameters for Improved Production of Bioactive Metabolite Butyrolactone I by Aspergillus terreus strains under Submerged Fermentation
D.L. Rudresh1,2*, Ratnadeep Paul Choudhury1 and Anamika Nakul1
1ITC Life Sciences & Technology Centre, 1st Main, 1st Phase, Peenya Industrial Area, Bangalore-560058, India
2Departmnet of Agricultural Microbiology, College of Horticulture, University of Horticultural Sciences, Navanagar, Bagalkot, Karnataka, India
*Corresponding author
Abstract:

Aspergilli, a large and diverse genus of ubiquitous filamentous fungi are the source of diverse secondary metabolites that can be used in the development of medications to treat diseases. Butyrolactone I is produced as a secondary metabolite by A. terreus. Butyrolactone I is a potent inhibitor of the eukaryotic cyclin-dependent kinases (CDK’s), protein kinases which control cell progression in all eukaryotes. Cyclin-dependent kinases are involved in numerous diseases in human beings like, cancer, stroke, diabetes, inflammation and AIDS. Butyrolactone I can become a life saving molecule in the above said diseases. In the present investigation the concentrations of carbon, nitrogen and phosphate sources and different fermentation conditions like temperature, media pH, agitation and incubation period were screened for their effect on the production of Butyrolactone I by two strains of A. terreus. The optimum nutrient concentrations and fermentation conditions for maximum production of Butyrolactone I were identified.


Keywords: Aspergillus terreus, Butyrolactone I, Nutrient concentrations, Fermentation conditions
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How to cite this article:

Rudresh, D.L., Ratnadeep Paul Choudhury and Anamika Nakul. 2019. Optimization of Nutrients and Process Parameters for Improved Production of Bioactive Metabolite Butyrolactone I by Aspergillus terreus strains under Submerged Fermentation.Int.J.Curr.Microbiol.App.Sci. 8(4): 614-624. doi: https://doi.org/10.20546/ijcmas.2019.804.067