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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(4): 245-252
DOI: https://doi.org/10.20546/ijcmas.2019.804.026


Role of Highly Sensitive C- Reactive, Protein, Interleukin-6 and Procalcitonin in Early Diagnosis of Neonatal Sepsis
Parul Singhal*, Vichal Rastogi and Ayesha Nazar
Department of Microbiology, School of Medical Sciences and Research, Sharda University, Greater Noida-201306, Uttar Pradesh, India
*Corresponding author
Abstract:

The diagnosis of neonatal sepsis is difficult because clinical manifestation is non-specific. Timely detection and treatment will help in decreasing mortality and morbidity. Blood culture is gold standard but the diagnosis is often retrospective. Thus there is a need for an alternative method which is more rapid, reliable and sensitive. This study was designed to determine the sensitivity, specificity, NPV, PPV and accuracy of hs-CRP, IL-6 and PCT levels, as a diagnostic marker of EONS. 206 neonates with sign and symptoms of sepsis admitted in NICU were included in this study. Blood culture was performed by Bac T/Alert 3D method, hs-CRP, IL-6 and PCT by ELISA. Low birth weight and prematurity were the most common risk factors present in 74% of EOS and 66% of LOS cases. Prolonged IV antibiotics were a risk factor in 26.4% in EOS and 50% in LOS. CoNS (44.1%) was the predominant bacterial pathogen isolated, followed by Staphylococcus aureus (11.7%), Escherichia coli (11.7%), Acinetobacter baumanii (8.8%) and Klebsiella pneumoniae (8.8%) in EOS cases. Cut off value of 5 mg/ml for hs-CRP, <20 pg/ml for IL-6 and <12 pg/ml for PCT were taken as negative. PCT is more sensitive and specific in EOS than IL-6 followed by hs-CRP. Both PCT and IL-6 are equally good markers, if patient presented later.


Keywords: Blood culture, Neonatal sepsis, EONS (Early onset neonatal sepsis), LONS (Late onset neonatal sepsis), Hs-CRP (Highly Sensitive C-reactive protein), (PCT) Procalcitonin, IL-6 (Interleukin-6)
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How to cite this article:

Blood culture, Neonatal sepsis, EONS (Early onset neonatal sepsis), LONS (Late onset neonatal sepsis), Hs-CRP (Highly Sensitive C-reactive protein), (PCT) Procalcitonin, IL-6 (Interleukin-6)Int.J.Curr.Microbiol.App.Sci. 8(4): 245-252. doi: https://doi.org/10.20546/ijcmas.2019.804.026