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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 359-367
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.041


Association between two TIM-1 Promoter SNPs (-416G>C and -1454G>A) and Allergic Rhinitis in Egyptian Patients
Amal Abdalmonem Ibrahim Amin1* and Marian Asaad Gerges2
1Department of Microbiology and Immunology, Faculty of Medicine, Fayum University, Egypt

2Department of Microbiology & Immunology, Faculty of Medicine, Zagazig University, Egypt
*Corresponding author
Abstract:

T cell/transmembrane immunoglobulin and mucin (TIM) molecules have a critical role in regulating immune responses.TIM-1 which is highly polymorphic in human has many nucleotide polymorphisms(SNPs) that have been studied for their role in allergic diseases, but the results were not consistent. The aim of study was to investigate the possible association between two TIM-1 promoter SNPs (-416G>C and -1454G>A) and allergic rhinitis(AR) in Egyptian patients sensitized to house dust mites. A further aim, was to assess the relationship between these SNPs and the level of house dust mites specific IgE. In a case-control study, a total of 30 AR patients who had positive skin prick test (SPT) to house dust mites were compared to 20-matched healthy volunteers regarding the two SNPs using restriction fragment length polymorphism(RFLP) technique. House dust mites specific IgE was measured in both groups using ELISA test and the results of both groups were compared.TIM-1 promoter SNPs(-416G>C&-1454G>A) were not significantly associated (P>0.05) with AR in Egyptian patients sensitized to house dust mites. Furthermore, no significant association (P>0.05)was found between the different genotypes at these SNPs and the level of house dust mites specific IgE. TIM-1 promoter polymorphisms (-416G>C &-1454G>A)do not contribute to the risk of development of AR in Egyptian patients.


Keywords: TIM-1,
Allergy,
Rhinitis,
SNPs,
IgE,
RFLP
technique
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How to cite this article:

Amal Abdalmonem Ibrahim Amin and Marian Asaad Gerges. 2016. Association between two TIM-1 Promoter SNPs (-416G>C and -1454G>A) and Allergic Rhinitis in Egyptian Patients.Int.J.Curr.Microbiol.App.Sci. 5(2): 359-367. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.041