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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 338-343
DOI: http://dx.doi.org/10.20546/ijcmas.2016.502.039


Sensitivity and specificity of Anti-mutated Citrullinated vimentin antibodies compared with Anti-cyclic Citrullinated Peptides in patients of Rheumatoid arthritis
Saurabh Agarwal*, Sippy Agrawal, Manoj Kumar and Arun Kumar Pandey
Institution M.L.B. Medical College Jhansi (U.P), India
*Corresponding author
Abstract:

Rheumatoid arthritis is a chronic systemic inflammatory autoimmune disease primarily characterized by a bilateral symmetrical polyarticular arthritis, which is often erosive.The last 5 years have seen the emergence and establishment of antibodies to citrullinated antigens as the diagnostic marker for rheumatoid arthritis (RA). Initially, these were detected using a synthetic peptide, which has undergone a number of modifications to give a diagnostic test with a sensitivity of 65–80% and a specificity of >95%. Antibodies to citrullinated vimentin were first described in 1994 as a highly specific marker for RA (anti-Sa). However, no easily performed assay for these antibodies has been available. Among them, antibodies against cyclic citrullinated peptides (CCP) are useful for diagnosing RA. antibodies to mutated citrullinated vimentin (MCV) were described recently in RA. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients. This study included 92 patients with Rheumatoid arthritis (RA) an 35 matching healthy controls. Blood samples were obtained from patients and controls for erythrocyte sedimentation rate (ESR),C reactive protein (CRP), rheumatoid factor (RF). Anti-CCP2 and anti-MCV were determined using ELISA technique. RA group was significantly higher than control group as regard ESR, CRP, RF, Anti-CCP, and Anti- MCV. It was concluded, compared to ACCP, anti-MCV has approximately the same accuracy for the diagnosis of rheumatoid arthritis.


Keywords: Anti-cyclic citrullinated peptide (anti-CCP2); Anticitrullinated vimentin antibody (anti-CMV); Rheumatoid arthritis (RA).
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How to cite this article:

Saurabh Agarwal, Sippy Agrawal, Manoj Kumar and Arun Kumar Pandey. Sensitivity and specificity of Anti-mutated Citrullinated vimentin antibodies compared with Anti-cyclic Citrullinated Peptides in patients of Rheumatoid arthritis.Int.J.Curr.Microbiol.App.Sci. 5(2): 338-343. doi: http://dx.doi.org/10.20546/ijcmas.2016.502.039