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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(12): 538-543
DOI: http://dx.doi.org/10.20546/ijcmas.2016.512.059


Progressive Decline in Pulmonary Functions in Adolescents with Chronic Hepatitis C Infection
S.M. Hassan1*, Heba Mohammed El Ashry2 and S. Abd-Elsalam2
1Pediatric Department, Faculty of Medicine, Tanta University, Egypt
2Tropical Medicine Department, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Chronic hepatitis C infection is considered now a multi-system disease, affecting nearly all body system. Hepatic affection of such viruses are widely evaluated while extra-hepatic manifestations (including lungs)still need more studies, especially in children and adolescents . To evaluate if chronic HCV (CHCV) infection without treatment is associated with progressive deterioration of pulmonary functions. Fifty adolescent patients with CHCV infection (12-18 years) and 50 control health subjects included in the study, with full hepatic evaluation beside pulmonary function tests (PFTs) at the start of the study. PFTs were repeated in patient group after 6 and 12 months and evaluated in comparison to start results and to control group. There was a gradual deterioration of PFT in adolescent patients with CHCV infection reached a significant levels(FEV1 89 ± 1.3,FVC 88 ± 0.8,  FEV1/FVC  91 ± 1.1) when compared to healthy control group(FEV1 96 ±  1.9,FVC  95 ± 1.2, FEV1/FVC  97 ±1.1  )with P value (0.02,0.03,0.01)respectively. Progressive decline in pulmonary functions is observed in adolescents with chronic HCV infection, but more researches are needed to further explore such deteriorations.


Keywords: Chronic Hepatitis B and C, FEV1,FVC,Pulmonary functions.
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How to cite this article:

Hassan, S.M., Heba Mohammed El Ashry and S. Abd-Elsalam. 2016. Progressive Decline in Pulmonary Functions in Adolescents with Chronic Hepatitis C Infection.Int.J.Curr.Microbiol.App.Sci. 5(12): 538-543. doi: http://dx.doi.org/10.20546/ijcmas.2016.512.059