International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:2, February, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 317-322

Anti-diabetic Profile of Extract, Kolaviron, Biflavonoids and Garcinoic acid from Garcinia kola seeds
M.K. Tchimene1*, A. O. Anaga2, C.E.C. Ugwoke3, O.J. Onoja1, C. O. Ezugwu3, C. Okunji1 and M.M. Iwu1
1International Centre for Ethnomedicine and Drug Development, 110 Aku Road,
Nsukka, Nigeria
2Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, UNN, Nsukka, Nigeria
3Department of Pharmacognosy and Environmental Medicine, UNN, Nsukka, Nigeria
*Corresponding author

Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, and neuropathy and causing neurological disorders due to perturbation in utilization ofglucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Garcinia kola seeds, has beenclaimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic activityof ethanol extract, the fraction and compounds of G. kola seeds. The results showed thatthe extract, fraction, compounds and the reference drug (glibenclamide) showed different levels of antidiabetic effect. However, GB2 gave the best antidiabetic effect which is an improvement from that of the extract. The effect of GB2 was similar to glibenclamide.

Keywords: Alloxan, Diabetes mellitus, Garcinia kola, Blood glucose.

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How to cite this article:

M.K. Tchimene, A. O. Anaga, C.E.C. Ugwoke, O.J. Onoja, C. O. Ezugwu, C. Okunji1 and M.M. Iwu. 2016. Anti-diabetic Profile of Extract, Kolaviron, Biflavonoids and Garcinoic acid from Garcinia kola seedsInt.J.Curr.Microbiol.App.Sci. 5(2): 317-322. doi:
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