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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 2669-2678
DOI: https://doi.org/10.20546/ijcmas.2019.801.281


Detection of Circulating Dengue Virus Serotypes in a Tertiary Care Centre in Central Kerala, 2016
Kavitha R. Nair1, Seema Oommen1*, O.A. Jagan3 and Vidya Pai2
1Department of Microbiology, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India
2Department of Microbiology, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India
3Department of Virology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India
*Corresponding author
Abstract:

Dengue is the most common mosquito-borne viral infection in tropical and sub-tropical countries. Dengue virus, a single stranded positive sense RNA virus belongs to the genus Flavivirus in the family Flaviviridae. Both Aedes aegypti and Aedes albopictus are the main vectors for dengue virus in India. Dengue illnesses are caused by one or more of the serologically related viruses namely DENV-1, DENV-2, DENV-3, DENV-4 and the newly identified DENV-5.India has faced a dramatically expanded dengue virus transmission over the last few decades, with rapidly changing epidemiology. In recent years, India has reported increased incidences of concurrent infection with multiple serotypes of dengue viruses (DENV). In the present study, we have identified the circulating dengue virus serotypes in a tertiary care centre in Central Kerala in 2016. A prospective study was conducted in the Department of Microbiology, of a tertiary care centre in Central Kerala from January 2016 to December 2016. A total of 274 adult patients whose serum samples were NS1 positive were further subjected to conventional multiplex RT- PCR. Out of 274, Dengue RT PCR was positive for 159 (58%) samples. Of 159, 64(40.3%) were identified as DENV-1, 55 (34.6%) DENV-2, seven (4.4%) DENV-3, two (1.25%) were DENV-4. Twenty- two cases (13.8%) were co-infected with DENV- 1 and DENV-2, six (3.77%) with DENV-2 and DENV-4 and three (1.88%) with DENV-2 and DENV-3. All the four dengue serotypes circulated in Kerala in the year 2016, of which DENV-1 was found to be the predominant serotype followed by DENV-2.


Keywords: Dengue, Dengue serotypes, Co-infecting dengue serotypes, DENV 1-4
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How to cite this article:

Kavitha R. Nair, Seema Oommen, O.A. Jagan and Vidya Pai. 2019. Detection of Circulating Dengue Virus Serotypes in a Tertiary Care Centre in Central Kerala, 2016.Int.J.Curr.Microbiol.App.Sci. 8(1): 2669-2678. doi: https://doi.org/10.20546/ijcmas.2019.801.281