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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
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Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2019.8(1): 954-962
DOI: https://doi.org/10.20546/ijcmas.2019.801.104


The Associations of Serum AMH, Vitamin D, FSH and AFC in Different Age Groups of Infertile Women
Hiba H. Kadhim* and Salman A. Ahmed
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq
*Corresponding author
Abstract:

The objective of our study was to identify the associations between the tests that used in ovarian reserve assessment: Anti-Mullerian hormone (AMH), fol¬licle stimulating hormone (FSH) and antral follicle count (AFC) and to distinguish the most reliable markers for ovarian reserve in order to select an adequate strategy for the initial stages of infertility treatment and identify the effect of vitamin D on the ovarian reserve and its correlation with AMH. Anti-mullerian hormone (AMH) is expressed only in the gonads. In female it’s secreted by adult granulosa cells of the ovary. The levels of AMH reflect the number of preantral follicles and thus as a marker of oocyte pool which is a germinal reserve of the ovary for reproduction. Vitamin D is a fat-soluble vitamin that belongs to the family of steroid hormones. It has a biologically plausible role in female reproduction. In this paper AMH, FSH and Vitamin D was determined by enzyme linked immunosorbent assay in: 60 infertile women with PCOS (cases) undergoing IVF and 30 healthy women had one child at least (control). The antral follicle count (AFC) was recorded for each female in case group. The AMH and 25(OH) D levels in cases were lower than that of control, while FSH level in cases was higher than control group. The AMH in cases was significantly decreased with increasing age. The AFC was inversely associated with age. There was a significant positive association between ovarian response in terms of the antral follicle count and AMH levels, there was no association between ovarian response in terms of the AFC with 25(OH)D and FSH implying that AMH can be used as a good predictor of ovarian reserve and ovarian response. The correlation between 25(OH)D and AMH among women ages 36-42 showed that AMH levels decreased significantly with increasing 25(OH)D levels, and was found no statistically significant correlation between 25(OH)D and AMH among women under the age of 36.


Keywords: Anti-Mullerian Hormone, Follicle stimulating hormone, Mullerian inhibiting substance, Vitamin D
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How to cite this article:

Hiba H. Kadhim and Salman A. Ahmed. 2019. The Associations of Serum AMH, Vitamin D, FSH and AFC in Different Age Groups of Infertile Women.Int.J.Curr.Microbiol.App.Sci. 8(1): 954-962. doi: https://doi.org/10.20546/ijcmas.2019.801.104