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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(12): 340-351
DOI: https://doi.org/10.20546/ijcmas.2018.712.042


Non-Antibiotic Compounds: The Activity of the NSAID Diclofenac on Bacteria- A Review
Agostinho Alves de Lima e Silvaand Priscila Martins Silva
Department of Microbiology and Parasitology, Biomedical Institute, Federal University of the State of Rio de Janeiro (UNIRIO), Frei Caneca St, no. 94, Rio de Janeiro, RJ, Brazil
*Corresponding author
Abstract:

Bacterial multidrug resistanceis a phenomenon that has been growing with increasing speed worldwide. New mechanisms of resistance have been described in different bacterial pathogens, representing a threat to effective treatments of common infectious diseases with currently available drugs. The use of drugs known as "non-antibiotics is among the alternative approaches to the use of conventional antibiotics. This approach has been studied in order to counteract the global threat of multidrug resistance.This group of drugs includes various non-steroidal anti-inflammatory drugs (NSAIDs).The NSAID diclofenac has demonstrated broad-spectrum antimicrobial activity in vitro and in vivo. In addition, this drug has an synergistic antibacterial effect when combined with certain other drugs. It may also show anti-biofilm activity, and may inhibit or decrease the activity of certain virulence factors in some bacterial pathogens.


Keywords: Non-antibiotics, Diclofenac, Anti-bacterial action, Anti-biofilm activity
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How to cite this article:

Agostinho Alves de Lima e Silva and Priscila Martins Silva. 2018. Non-Antibiotic Compounds: The Activity of the Nsaid Diclofenac on Bacteria- A Review.Int.J.Curr.Microbiol.App.Sci. 7(12): 340-351. doi: https://doi.org/10.20546/ijcmas.2018.712.042