International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Original Research Articles                      Volume : 5, Issue:2, February, 2016

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : /
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(2): 245-253

Evaluation of Antistaphylococcal Activity of Ellagic Acid Extracted
from Punica granatum Fruit Peel on MRSA
Bindu1, V.P. Jayachandran2 and C.D. Elcey3*
1Department of Botany, Bharathiar University, Coimbatore, Tamilnadu, India
2Microbiology Section, PIMSRC, Thiruvalla, 689101 Kerala, India
3Department of Life sciences, Kristu Jayanti College (Autonomous), Bangalore- 560 077, Karnataka, India
*Corresponding author

Multiple drug resistance is always a challenge to any therapy. Phyto-compounds are one of the major sources of chemical for multiple drug resistance. The compounds used in the present study was extracted from pomegranate fruit peel and purified. Major compound extracted was ellagic acid. The extracted compound was tested for its antibacterial efficacy against wound isolates of Staphylococcus aureus and Methicillin resistant S. aureus (MRSA) using agar well diffusion method. Comparative study was done with gentamicin sulphate. Minimum inhibitory concentration of the ellagic acid was determined by microtube broth dilution method. The results showed that the biological activity of ellagic acid was lesser than gentamicin. Also, the minimum effective dose of ellagic acid was found to be 125μg/ml to MRSA, while the minimum effective doses of gentamicin was 30μg/|ml.

Keywords: MRSA, Ellagic acid, Punica granatu.

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How to cite this article:

Bindu, I., V.P. Jayachandran and Elcey, C.D. 2016. Evaluation of Antistaphylococcal Activity of Ellagic Acid Extracted from Punica granatum Fruit Peel on MRSA.Int.J.Curr.Microbiol.App.Sci. 5(2): 245-253. doi:
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.