National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
To investigate the relation of the resistin gene promoter single nucleotide polymorphism (RETN–420C>G) with the serum resistin concentration and rheumatoid arthritis (RA) risk, and if there is any association with the disease activity and autoimmunity. This study included 128 patients with RA (64 active and 64 in remission) and 64 controls. Serum resistin was measured for all subjects by ELISA. Other markers of inflammation and disease activity were also assessed. All subjects were genotyped for RETN–420C>G polymorphism using PCR-RFLP. Serum resistin was significantly higher in active RA patients compared to inactive patients and controls. Patients with CG and GG genotypes had increased risk of RA compared to CC carriers (OR = 1·88, P= 0.049, OR = 4.84, P = 0.046, respectively). Highly significant level of resistin was detected with variant genotypes. Highly significant association was found between the investigated polymorphism and the parameters of the disease activity, but not autoimmunity. This is the first study suggesting the relationship between RETN –420C>G polymorphism and both the risk of RA and its activity, but not autoimmunity. More studies of different populations and larger samples are required to confirm these observations.
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