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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2018) [Effective from January 1, 2018]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(11): 83-88
DOI: https://doi.org/10.20546/ijcmas.2018.711.012


A Study of Synergistic Antibacterial Activity of Silver Nanoparticles with Antibiotics against Multi-Drug Resistant Pseudomonas aeruginosa in Intensive Care Units of A Tertiary Care Hospital
Komal Mirlekar*, Anjali Swami, Sujata Baveja and Shanta Shubhra Das
Department of Microbiology, Lokmanya Tilak Municipal Medical College & GH, Sion, Mumbai, Maharashtra - 400 022, India
*Corresponding author
Abstract:

Evolution of multi drug resistant isolates has become rampant in today’s world. The credit of this goes to the incomplete dosage and irrational use of antibiotics. The human brains are now in search of alternate methods. Use of Silver nanoparticles is one amongst them. In the following study, 50 multi-drug resistant clinical isolates of P. aeruginosa acquired from the intensive care units were tested with antibiotics, AgNps and AgNp-antibiotic conjugates. The conjugates were prepared by impregnating 30 µl of AgNps in sterile plain disks and the antibiotic disks separately. The antibiotics tested were Ciprofloxacin, Amikacin, Ceftazidime and Piperacillin-Tazobactam. Maximum number of isolates showed zone enhancement with both AgNp and AgNp – antibiotic conjugates. Fewer numbers of isolates that did not show enhancement may have different mechanisms of resistance like point mutations. Nanoparticles are not able to overcome point mutations. Thus, Nanotechnology has served to be a boon to overcome the massive war against Multidrug resistant isolates.


Keywords: Synergistic activity, Nanoparticles with antibiotics, Multi-drug resistant organisms
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How to cite this article:

Komal Mirlekar, Anjali Swami, Sujata Baveja and Shanta Shubhra Das. 2018. A Study of Synergistic Antibacterial Activity of Silver Nanoparticles with Antibiotics against Multi-Drug Resistant Pseudomonas aeruginosa in Intensive Care Units of A Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 7(11): 83-88. doi: https://doi.org/10.20546/ijcmas.2018.711.012