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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2018) [Effective from January 1, 2018]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2017)
[Effective from January 1, 2017]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here
journals IJCMAS
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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(11): 972-988
DOI: https://doi.org/10.20546/ijcmas.2018.711.113


Role of Adjuvants in Vaccine Preparation: A Review
Pushpa Makwana, Irshadullahkhan Kalyani, Dhruv Desai, Dharmesh Patel, Pramod Sakhare and Dushyant Muglikar
Department of Veterinary Microbiology, College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari-396445, Gujarat, India
*Corresponding author
Abstract:

Adjuvants are most important component of vaccine usually added with the immunogen in vaccine preparation. Since long back, adjuvants have been used to reduce immunogen dose, improve longevity and enhance the efficacy of vaccine. Though its wide use in pharma industries for vaccine manufacturing, it produce side effects, sometimes potent adverse reaction. From the earlier foundation of adjuvant activity, still there are limited resources of adjuvant have been frequently used by manufacturer. Role of adjuvants are most important factor for a particular vaccine preparation. With best possible way, adjuvants can act as key role in vaccines. Biological products, synthetic available substances and ethno medicinal and pharma sources need to be explore for finding out newer adjuvants. Most of the next generation adjuvants are in clinical trials. Here, we have reviewed all possible, currently available and commonly used adjuvants with newly developed and recently tested adjuvant. Hence, we have put some light on emphasis of adjuvant research and development, as there is need of potent, safe, efficacious and non-reactogenic substances that can be used as adjuvant.


Keywords: Adjuvants, Immunogen, Vaccine, Next generation adjuvants, Synthetic adjuvants
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How to cite this article:

Pushpa Makwana, Irshadullahkhan Kalyani, Dhruv Desai, Dharmesh Patel, Pramod Sakhare and Dushyant Muglikar. 2018. Role of Adjuvants in Vaccine Preparation: A Review.Int.J.Curr.Microbiol.App.Sci. 7(11): 972-988. doi: https://doi.org/10.20546/ijcmas.2018.711.113