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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(10): 769-776
DOI: https://doi.org/10.20546/ijcmas.2018.710.085


Efficacy of Bacterial Collagenase Therapy in RFM Cows Assesed through Concentration of Serum and Lochial NAGase
P. Mohan1*, K. Krishnakumar2, K. Kulasekar3, S.M.K. Karthickeyan4 and M. Murugan5
1Department of Veterinary Gynaecology and Obstetrics, Veterinary College, Shivamogga -577 204, KVAFSU, India
2Cattle and Buffalo Breeding Unit, PGRIAS, Kattupakkam- 603203, India
3Department of Clinics, Madras Veterinary College, Vepery- 600 007, India
4Department of Animal Breeding Genetics, Madras Veterinary College, Vepery-600 007, India
5VUTRC, Melmaruvathur, India
*Corresponding author
Abstract:

The study was conducted in cases of RFM presented within 12 to 24 hours after parturition to Obstetrics Unit of Madras Veterinary College, Chennai. Group I received placebo treatment with one litre of normal saline intravenously. Group II cows, treated with intrauterine proteolytic bolus containing nitrofurazone, metronidazole and urea and antibiotic therapy (Inj. Streptopenicillin @ 20,000 units/kg body weight) without manual removal for 7 days. Groups III cows, received single dose of 2, 00,000 CDU of collagenase plus 40 mg of calcium chloride and 40 mg of sodium bicarbonate dissolved in one litre of normal saline at a pH of 7.5 intravenously through jugular vein (Eiler and Hopkins, 1993). Group IV received single dose of 2,00,000 U of collagenase intravenously. The data on the concentration of serum and lochial NAGase of all the different treatment groups with serum and lochia samples were collected. Further, collected data were compared and analyzed; which showed that the serum NAGase concentration was significantly (P<0.01) higher in group IV on day 0; group II on day 7; group II and IV on day 14; and the overall mean concentration was significantly (P<0.05) lower in groups I and III. The lochial NAGase concentration was significantly (P<0.05) higher in group IV on day 0 and group II on day 7 and 14. These results revealed that the administration of collagenase through intravenous route had achieved better healing and recovery.


Keywords: Serum, Uterine lochial NAGase, RFM, bacterial collagenase Efficacy, Cows
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How to cite this article:

Mohan, P., K. Krishnakumar, K. Kulasekar, S.M.K. Karthickeyan and Murugan, M. 2018. Efficacy of Bacterial Collagenase Therapy in RFM Cows Assesed through Concentration of Serum and Lochial NAGase.Int.J.Curr.Microbiol.App.Sci. 7(10): 769-776. doi: https://doi.org/10.20546/ijcmas.2018.710.085