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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(10): 656-663
DOI: http://dx.doi.org/10.20546/ijcmas.2016.510.073


Antibiotic Sensitivity Profile of Escherichia coli Associated with Specific Infections in a Nigerian Tertiary Health Institution
M.S. Odimayo1*, S.I. Nwadioha2, Joseph Adejoke Adijat1 and Daramola Gabriel Olugbenga3
1Department of Medical Microbiology and Parasitology, College of Medicine, Ekiti State University, Ado Ekiti, Nigeria
2Department of Medical Microbiology and Parasitology, College of Health Sciences, Benue State University, Nigeria
3Department of Medical Microbiology and Parasitology, Ekiti State University Teaching Hospital, Ado Ekiti, Nigeria
*Corresponding author
Abstract:

To determine the prevalence of Escherichia coli and the drug susceptibility profile. A twenty –six month retrospective review of culture results of clinical specimens in Ekiti State University Teaching Hospital Medical Microbiology Laboratory from January, 2014 to February, 2016 was done. A total of five hundred and twenty seven (26.4%) Escherichia coli isolates were recovered from 2000 clinical samples for cultures submitted to the laboratory during the 26 months review period. About fifty eight per cent of the isolates were from clinical samples of female patients with 33.6% increased incidence in the age group of 45 years and above. About sixty per cent (n=315/527) of the isolates were from urine samples while 0.4% least isolation rate (n=2/527) was from cerebrospinal fluid samples. The following antibiotics were found to be effective against Escherichia coli isolates; Nitrofurantoin (83.5%)- primarily for urinary tract infection, Ceftriaxone (73.6%), Gentamicin (56.7%) and averagely Ciprofloxacin (49.3%). On the other hand, the following antibiotics showed poor activities; Ampicillin (1.3%), Cefuroxime (20%) and Amoxicillin-clavulanic acid (30.4%). A high rate of multi-drug resistance was noted in this study, especially to commonly used first line antibiotics. Ceftriaxone, Gentamicin and Ciprofloxacin are choices to be considered when treating infections due to E.coli in this geographical location.


Keywords: coli, Antimicrobial susceptibility, infections,Ekiti state,Nigeria.
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How to cite this article:

Odimayo, M.S., S.I. Nwadioha, Joseph Adejoke Adijat and Daramola Gabriel Olugbenga. 2016. Antibiotic Sensitivity Profile of Escherichia coli Associated with Specific Infections in a Nigerian Tertiary Health Institution.Int.J.Curr.Microbiol.App.Sci. 5(10): 656-663. doi: http://dx.doi.org/10.20546/ijcmas.2016.510.073