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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(10): 605-616
DOI: http://dx.doi.org/10.20546/ijcmas.2016.510.068


Bacterial Pathogens of Surgical Site Infections in Cancer Patients at a Tertiary Regional Cancer Centre, South India
B.G. Sumathi*
Department of Microbiology, Kidwai Memorial Institute of Oncology, Bangalore 5600 29, India
*Corresponding author
Abstract:

A retrospective microbiological study of surgical site infections(SSIs) from oncological departments of Surgery, Gynaecology, Head and Neck and Oral oncology was evaluated to estimate the percentage resistance pattern of gram negative and gram positive bacteria from cancer patients. Surgical site infections are the nodal sites and direct index factor for the assessment of health-care associated infections in a hospital with a potential high risk for cancer patients. A total of 1546 post operative infected wound discharges and post operative drains in-situ discharges from surgical oncology departments were analysed between 2012 to 2014 for bacterial infections. Bacterial isolation was done by conventional laboratory methods in the department of microbiology. Susceptibility and resistance pattern to isolated pathogens were done by the conventional Stokes’ method of antibiotic testing and extended-spectrum beta-lactamases(ESBL) were estimated by conventional 3 disc synergy diffusion method. Anaerobic infections were not included in the study. One thousand five hundred and forty six post operative infected wound and discharges from drains in-situ were analysed which yielded polymicrobial and monomicrobial infections. Out of 1058 samples the predominant isolates was gram negative bacilli followed by gram positive cocci with 488 samples. The predominant pathogens were E.coli 632(59.73%);Klebsiella species148 (13.98%); Pseudomonas species 110(10.39%);Non fermenting gram negative bacilli 86(8.12%);Proteus species and Morganella morgani 62(5.86%); Citrobacter species20(1.89%) and Enterococci species262(53.68%); Staphylococcus aureus 202(41.3%); Methicillin Resistant Staphylococcus aureus 14(2.86%);Coagulase Negative Staphylococcus(CONS)8(1.6%);and β streptococci 2(.2%). Extended spectrum beta-lactamases production out of the total 1058 samples were E.coli 328 (31.00%); Klebsiella species32(3.02%); Non fermenting gram negative bacilli16(1.51%); Proteus species 12(1.13%); Pseudomonas species 6(0.56%) Citrobacter species 6(0.56%).Amongst the total gram negative bacilli(1058), SSI surgical oncology services had the maximum SSIs isolates 48.39%; followed by departments of gynaec oncology 20.79%; head and neck oncology 6.61%; oral oncology 1.70%. Among the gram positive cocci(488) surgical oncology department had the maximum isolates 40.98%; followed by gynaec oncology 31.14%; head and neck oncology 4.91%; oral oncology 1.63%. Poymicrobial infection isolates was 516(33.37%) and monomicrobial isolates was 386(24.96%). Bacterial surgical site infections is the complication of surgery. The spectrum of post operative oncological surgical site infections in a cancer hospital are a nidus for health-care associated infections and increased health care burden. Relevant oncological surgical risk factors and antibiotic therapy need be evaluated in high risk patients like cancer to avoid early mortality and morbidity. This is the first study on surgical site bacterial infections in cancer patients in our hospital, Kidwai Memorial Institute of Oncology, a regional cancer centre in South India.


Keywords: Cancer, Bacterial Surgical Site Infections, Solid tumors, Resistance, Gram Negative Bacilli, Gram positive  Cocci.
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How to cite this article:

Sumathi, B.G. 2016. Bacterial Pathogens of Surgical Site Infections in Cancer Patients at a Tertiary Regional Cancer Centre, South India.Int.J.Curr.Microbiol.App.Sci. 5(10): 605-616. doi: http://dx.doi.org/10.20546/ijcmas.2016.510.068