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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 2977-2985
DOI: https://doi.org/10.20546/ijcmas.2018.709.370


Nephroprotective Effect of Herbal Seed Extracts of Vigna unguiculta and Hordeum vulgare on Serum Biochemical Changes on Ethylene Glycol and Ammonium Chloride Induced Urolithiasis in Female Wistar Rats
Monika K. Patel1, Sunant K. Raval1*, Rakesh J. Modi2,Dasharath B. Sadhu1 and Mukesh T. Gehani1
1Department of Veterinary Medicine, 2Department of Livestock Production Management, College of Veterinary Science and Animal Husbandry,Anand Agricultural University, Anand, Gujarat, India
*Corresponding author
Abstract:

The experimental work was undertaken to study the therapeutic efficacy of aqueous, alcoholic and biherbal extracts of Vigna unguiculata (V.U.) and Hordeum vulgare (H.V.) on ethyleneglycol and ammonium choride induced urolithiasis in female wistar rats. Rats were dividedinto1 4groups. Each of 6 rats except lithiatic control group consist 8 rats. Group I and II served as lithiatic and vehicle control, respectively. In group I and III to XIV induction of urolithiasis was done by administration of 0.75 % (v/v) ethylene glycol and 2% (w/v) ammonium chloride along with drinking water for 28 days. Group II was given 0.5% sodium bicarbonate. After 28th day, the rats of urolithiatic treatment Groups III to XIV were given aqueous and alcoholic seed extract of V.U. and H.V. @ 200 mg/kg and 300 mg/kg bwt orally as either single extracts or combination as biherbal extracts (1:1) in 0.5 % sodium bicarbonate using syringe and rat gavage needle. Blood samples were collected. Confirmation of urolithiasis was done by evaluating serum biochemical parameters. However, increase level of serum glutamic-pyruvic transaminase, Blood Urea Nitrogen, uric acid, creatinine, calcium and phosphorus, while decreased level of serum total protein and serum magnesium were observed in urolithiatic groups as compared to vehical control group on 28th day. Results of serum biochemistry reveals aqueous and alcoholic extract of V.U. and H.V. possess good therapeutic efficacy against urolithiasis. The effect of biherbal alcoholic extract of the seeds was much better in restoring the values on 63rd day after treatment.


Keywords: Biherbal extract, Vigna unguiculata, Hordeum vulgare, Ethylene glycol, Ammonium chloride, Sodium bicarbonate, Urolithiasis, Wistar rat
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How to cite this article:

Monika K. Patel, Sunant K. Raval, Rakesh J. Modi, Dasharath B. Sadhu and Mukesh T. Gehani. 2018. Nephroprotective Effect of Herbal Seed Extracts of Vigna unguiculta and Hordeum vulgare on Serum Biochemical Changes on Ethylene Glycol and Ammonium Chloride Induced Urolithiasis in Female Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 7(9): 2977-2985. doi: https://doi.org/10.20546/ijcmas.2018.709.370