Corticotrophin-releasing hormone is secreted during pregnancy in maternal and fetal from the placenta. Increased levels of Corticotrophin-releasing hormone (CRH) related with increased of serum Cortisol. In addition adrenocorticotropic hormone ACTH is usually changes during pregnancy and increase in late pregnancy and throw delivery. levels of C-reactive protein CRP related with adverse pregnancy outcomes, including preterm delivery. The present study was conducted to examine BMI, Hb, Red Blood Cells (RBC), Random Blood Sugar (RBS), creatinine, albumin and uric acid levels in pregnant women and examined the levels of h-CRP, adrenocorticotropic hormone (ACTH) and Cortisol levels. The study appeared significantly decreased in each of Hb, RBC, Creatinine, albumin and non significantly decrease in random blood sugar (RBS) in pregnant women as compared with control groups, also there was significant increased in BMI and uric acid and non significantly increased in Age in pregnant women when compared with control groups. In addition of that, the result appeared significantly increased in each of ACTH, Cortisol in pregnant women as compared with control groups. But there was not significantly increased in level of h-CRP in pregnant women compared with control groups, in addition of that there is Positive significant correlations were observed between-CRP and ACTH, but there was negative correlation was found between h-CRP and Cortisol in pregnant women.