Fifty cases were screened for CRP those who are having various ailments including high blood pressure, diabetic mellitus with polyneuropathy, oral cavity infection and hepato-spleenomegaly of different aetiologies. In this hospital (Sree Narayana Medical Trust, Varkala) we have screened the serum samples by latex agglutination test. It is a specific test. CRP is a more sensitive and accurate reflection of the acute phase response than the ESR (Erythrocyte Sedimentation Rate). CRP appears and disappears more quickly than changes in ESR. There for your CRP level may drop to normal following successful treatment, whereas ESR may remain elevated for a longer period. CRP levels will be very high in the arthritis, increased serum CRP concentrations are positively associated with the risk of future coronary events such as coronary artery dices cerebrovascular dices, peripheral arterial dices. The use of CRP for these purposes requires the use of hs CRP assay that have detection limits less than 0.3mg/L. Several automated immunoturbidimetric and immunonephelometric assays are commercially available and are capable of sensitive and precise measurements at low concentrations of CRP. hs CRP to be a stronger predications of risk than LDL cholesterol.