Neurocysticercosis (NCC) is a clinical condition in humans, which infects brain caused by a encysted larvae, cysticercoid of Taenia solium. NCC is common disease but its diagnosis remains problematic. Suspected cases of Neurocysticercosis were underwent CT/MRI neuroimaging and also blood samples were collected. Enzyme Linked Immunosorbent Assay (ELISA) used for detction of IgG antibodies in serum samples using Execretory-Secretory (ES) antigen. Positivity for IgG antibodies seen in 59 patients about 71.9%. ES antigen was positive in 4(44.4%) of 9 patients with live cysts, 18 of 61 patients (29.5%) with degenerative cysts and only 1 of 6 patients ( 16.6%) with calcified cysts. Maximum positive results on immunological tests were obtained when the number of lesions were high, when the lesions were in contact with CSF and when there were live cysts. Comparative study of Radioimaging and ELISA gives better results and helpful in early diagnosis and accurate treatment.