Sexually transmitted diseases are a group of must common communicable diseases that have gained importance in all societies, all over the world in recent years. They cause loss of years of health & productive life. There diseases are caused by wide range of Bacterial, Viral, Protozoa & Fungal agents, which include emerging & reemerging infectious agents. There causative organisms are after delicate and do not remain viable for long out side the body. Survival of there organisms depend on transmission by direct contact hetman mucosal surfaces. The parent study is undertaken to known the seroprevalence of HIV, HBV, HCV & Syphilis among high risk groups & general population attending STD clinic and Obstetrics & Gynecology department at KIMS, Amalapuram. A total of 250 STD patients with suspected sexually transmitted disease from Amalapuram & surrounding areas formed study group & 250 antenatal women attending antenatal clinics for checkup, considered as representative of general population, are taken as control group & were screened for HIV, HBV, HCV & Syphilis out of 250 samples of study group, 10 (28.6%) were reactive for HIV, 26 (10.4%) Positive for HBsAg antibodies, 10 were positive for HCV & 30 (12.6%) were reactive for Syphilis. Out of 250control samples, 5 (2%) were reactive for HIV, 24 (9.6%) Positive for HBV, 2 (0.8%) positive for Syphilis. In the study group HIV (28.4%) infectious are more in females where as HBV (15.6%) and Syphilis infectious (6.4%) are more common in Males. The most common age group affected was 20 29 yrs in both groups. Association of other STD`s with HIV was 28 % in study group and 3.2 % in control group.