Urinary tract infections (UTI) are the common infections in outpatients as well as in hospitalized patients. E. coli is the causative pathogen in 50 80% of cases. Non- E.coli infections are more common in complicated UTIs. Studying the host factors that affect urinary etiology and antibiotic susceptibility, helps in formulating appropriate therapeutic strategies. 200 urine samples from adult patients constituting 100 each from community and hospital origin were processed. Data on various host characteristics in the two groups were obtained by review of medical records and questionnaire method. Only those samples yielding single Gram negative uropathogen were selected. Each host characteristic was compared across uropathogen groups using chi square test. Significant P values for association between pregnancy and infection with Klebsiella pneumoniae were found in the community acquired (chi-square=4.76; p value < 0.05) and hospital acquired (chisquare= 9.36; p value < 0.005) UTI groups. In the hospital acquired UTI group, infection by Escherichia coli (chi-square=4.52; p value < 0.05) & Klebsiella pneumoniae (chi-square=4.69; p value < 0.05) were significantly associated with urinary catheterization and infection by Pseudomonas aeruginosa (chisquare= 8.62; p value < 0.005) with diabetes. UTIs due to Klebsiella pneumoniae were more likely in pregnancy and due to Pseudomonas among the diabetics. Urinary catheterization was more often associated with E.coli and Klebsiella pneumoniae UTI. An understanding of the host characters and their association with individual uropathogens is essential to tailor the empirical antibiotic therapy.